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Clemastine fumarate

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Identification
Molecular formula
C21H26ClNO5
CAS number
15686-50-5
IUPAC name
[2-(4-chlorophenyl)-1-methyl-ethyl]-(2-furylmethyl)ammonium;chloride
State
State

At room temperature, clemastine fumarate is in a solid state, generally appearing as a crystalline powder.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
202.00
Boiling point (Kelvin)
475.15
General information
Molecular weight
459.98g/mol
Molar mass
459.9830g/mol
Density
1.0500g/cm3
Appearence

Clemastine fumarate typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of [2-(4-chlorophenyl)-1-methyl-ethyl]-(2-furylmethyl)ammonium;chloride

The solubility of the compound [2-(4-chlorophenyl)-1-methyl-ethyl]-(2-furylmethyl)ammonium;chloride can be characterized by several key factors:

  • Polarity: This compound exhibits significant polarity due to the presence of both ammonium and chloride ions. The ionic nature typically facilitates solubility in polar solvents like water.
  • Hydrogen Bonding: The ammonium part is capable of hydrogen bonding, which enhances solubility in aqueous solutions.
  • Chloride Ion Contribution: The chloride ion contributes to increasing solubility, as it is generally soluble in water.

Although strong solubility is expected in polar solvents, the presence of the bulky 4-chlorophenyl and furyl groups may introduce steric hindrance, potentially affecting the **overall solubility**. Factors affecting solubility include:

  1. Temperature: Increased temperature often enhances solubility.
  2. pH levels: Solubility may vary under different pH conditions, especially since ammonium compounds can change their protonation states.
  3. Presence of other ions: The solubility might also be influenced by the presence of other ions in the solution.

In summary, while [2-(4-chlorophenyl)-1-methyl-ethyl]-(2-furylmethyl)ammonium;chloride is likely to be soluble in polar solvents due to its ionic nature, the extent of its solubility can vary greatly based on environmental conditions and the molecular structure. A careful assessment is necessary to determine the exact solubility profile.

Interesting facts

Interesting Facts about [2-(4-chlorophenyl)-1-methyl-ethyl]-(2-furylmethyl)ammonium;chloride

This compound, which is a type of ammonium salt, showcases some intriguing characteristics that make it noteworthy within the field of chemistry. Here are some of the key points:

  • Role as a Quaternary Ammonium Compound: This compound belongs to the class of quaternary ammonium compounds, which are often known for their versatility and wide range of applications, particularly in biochemistry and medicinal chemistry.
  • Pharmacological Importance: Compounds like this one are frequently investigated for their potential medicinal properties. Research is ongoing into their roles as antitumor agents, antimicrobial agents, and in modulating neurotransmitter activity.
  • Structure-Activity Relationship (SAR): The unique structure that includes both aromatic and furan rings contributes to its reactivity and interaction with biological systems, making it a prime candidate for SAR studies.
  • Analytical Challenges: The complexities in its structure may present analytical challenges. Techniques such as NMR, HPLC, and mass spectrometry are crucial for pinpointing its behavior and understanding its interactions.
  • Environmental Considerations: Like many synthetic compounds, there is growing interest in assessing the environmental impact and potential bioaccumulation of this compound, which is essential for sustainable chemistry practices.

In the words of famed chemist Linus Pauling, "The best way to have a good idea is to have lots of ideas." This compound epitomizes this sentiment, inspiring chemists to explore its potential in various fields while highlighting the need for continuous innovation in research.

Indeed, the study of [2-(4-chlorophenyl)-1-methyl-ethyl]-(2-furylmethyl)ammonium;chloride opens the door to numerous scientific inquiries, making it a fascinating subject for both seasoned scientists and budding chemistry students alike.

Synonyms
N-(p-Chloro-alpha-methylphenethyl)furfurylamine hydrochloride
14898-09-0
FURFURYLAMINE, N-(p-CHLORO-alpha-METHYLPHENETHYL)-, HYDROCHLORIDE (+-)-