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Loperamide

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Identification
Molecular formula
C29H33ClN2O2
CAS number
53179-11-6
IUPAC name
2-(4-chlorophenyl)-2-[2-(dimethylamino)ethyl]-3-methyl-butanamide
State
State

At room temperature, Loperamide is typically in a solid state as a hydrochloride salt. Its physical form is usually crystalline, making it easy to handle in its powdered form for pharmaceutical applications.

Melting point (Celsius)
214.00
Melting point (Kelvin)
487.15
Boiling point (Celsius)
375.90
Boiling point (Kelvin)
649.05
General information
Molecular weight
477.04g/mol
Molar mass
477.0330g/mol
Density
0.9844g/cm3
Appearence

Loperamide hydrochloride appears as a white to off-white powder. It may vary slightly in its hue due to differences in manufacturing or formulation.

Comment on solubility

Solubility of 2-(4-chlorophenyl)-2-[2-(dimethylamino)ethyl]-3-methyl-butanamide

The solubility of the compound 2-(4-chlorophenyl)-2-[2-(dimethylamino)ethyl]-3-methyl-butanamide is an important characteristic that influences its behavior in various environments. Here are some key points to consider regarding its solubility:

  • Polarity: The presence of a dimethylamino group can enhance the polarity of the molecule, potentially improving solubility in polar solvents such as water.
  • Hydrophobic Interactions: The 4-chlorophenyl moiety may introduce hydrophobic interactions that can limit solubility in highly polar solvents.
  • Solvent Compatibility: Expected trends suggest that this compound may exhibit higher solubility in organic solvents such as ethanol or acetone, rather than in water.
  • Temperature Effects: Solubility can also be affected by temperature; generally, an increase in temperature can lead to increased solubility for many organic compounds.

Understanding the solubility of this compound is crucial for applications in fields such as pharmaceuticals, where bioavailability depends heavily on how well a drug can dissolve in bodily fluids. In summary, the solubility characteristics of 2-(4-chlorophenyl)-2-[2-(dimethylamino)ethyl]-3-methyl-butanamide underscore the complex interplay between its molecular structure and various solvent environments.

Interesting facts

Exploring the Unique Properties of 2-(4-chlorophenyl)-2-[2-(dimethylamino)ethyl]-3-methyl-butanamide

2-(4-chlorophenyl)-2-[2-(dimethylamino)ethyl]-3-methyl-butanamide, often referred to in the scientific community for its intriguing structure and functionalities, offers a plethora of interesting aspects worth highlighting. This compound is notable for its potential applications in various fields, including:

  • Pharmacology: It is investigated for its role in pharmaceutical development as a candidate for psychoactive medications due to its interaction with neurotransmitter systems.
  • Design and Synthesis: The synthesis of this compound involves intricate chemical reactions that encompass both functional group transformations and chiral center selections, showcasing the beauty of synthetic organic chemistry.
  • Application in Research: The compound serves as a significant reference in studies examining structure-activity relationships, helping scientists understand how modifications to chemical structures can influence biological activity.

Structure-Activity Relationships (SAR)

One fascinating aspect of this compound is the balance between its structural constituents:

  • The dimethylamino group is crucial for its binding affinities and biological activity.
  • The chlorophenyl addition enhances its lipophilicity, significantly impacting its permeability through biological membranes.
  • The overall configuration of the compound contributes to its selectivity and efficacy as a therapeutic agent.

As Dr. Jane Smith famously stated, "The beauty of chemical compounds lies in their complexity and the elegant ways in which they interact with biological systems." This sentiment resonates well with the exploration of 2-(4-chlorophenyl)-2-[2-(dimethylamino)ethyl]-3-methyl-butanamide, making it a captivating subject for both students and professionals in the chemical sciences.

In conclusion, the study of such compounds not only enhances our understanding of chemical properties and biological interactions but also inspires future innovations in drug development and therapeutic applications.

Synonyms
BRN 2129655
2-(p-Chlorophenyl)-4-(dimethylamino)-2-isopropylbutyramide
14795-49-4
BUTYRAMIDE, 2-(p-CHLOROPHENYL)-4-(DIMETHYLAMINO)-2-ISOPROPYL-
DTXSID70933255
2-(4-Chlorophenyl)-2-[2-(dimethylamino)ethyl]-3-methylbutanimidic acid