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Clonidine

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Identification
Molecular formula
C9H9ClN2
CAS number
4205-91-8
IUPAC name
2-(4-chlorophenyl)-2-(dimethylamino)acetonitrile
State
State

At room temperature, clonidine is in a solid state in the form of crystalline powder. It should be stored in a closed container to prevent it from absorbing moisture from the air.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
455.00
Boiling point (Kelvin)
728.15
General information
Molecular weight
192.66g/mol
Molar mass
192.6580g/mol
Density
1.2010g/cm3
Appearence

Clonidine typically appears as a white to off-white crystalline powder. It is usually supplied in its hydrochloride salt form for medical purposes. The compound is often odorless.

Comment on solubility

Solubility of 2-(4-chlorophenyl)-2-(dimethylamino)acetonitrile

The solubility of 2-(4-chlorophenyl)-2-(dimethylamino)acetonitrile, often referred to as a pharmaceutical intermediate, can be notably influenced by its structural characteristics. Here are several key points regarding its solubility:

  • Polar vs. Nonpolar: The presence of the dimethylamino group suggests that this compound has some polar characteristics, which may enhance its solubility in polar solvents.
  • Solvent Compatibility: It may dissolve well in solvents such as ethanol and dimethyl sulfoxide (DMSO), which are known to solubilize similar compounds due to their polar nature.
  • Limited Aqueous Solubility: As a nitrile, its solubility in water might be limited due to the hydrophobic character imparted by the 4-chlorophenyl group. This often results in decreased interaction with water molecules.
  • Temperature Effects: Like many chemical compounds, solubility may increase with temperature. Higher temperatures often allow for greater solvation of molecules.

In conclusion, while the solubility of 2-(4-chlorophenyl)-2-(dimethylamino)acetonitrile can vary significantly with different solvents and conditions, understanding its solubility can provide essential insights for practical applications in synthesis and pharmaceutical formulations.

Interesting facts

Interesting Facts about 2-(4-chlorophenyl)-2-(dimethylamino)acetonitrile

2-(4-chlorophenyl)-2-(dimethylamino)acetonitrile is a fascinating compound that's attracted attention in various fields, particularly in medicinal chemistry. Here are some noteworthy aspects:

  • Structure and Functionality: This compound features a unique structure that includes a dimethylamino group, which is known for its basicity and ability to interact with biological systems.
  • Pharmaceutical Relevance: Due to its structural properties, it is often explored in the synthesis of potential pharmacological agents, especially in the development of antidepressants and antipsychotic medications.
  • Role as a Building Block: The acetonitrile moiety is valuable in organic synthesis, serving as a pivotal building block for creating more complex molecules.
  • Chirality and Isomers: One of the intriguing points of interest is how modifications to its molecular structure can lead to various isomers, each potentially displaying different biological activity.
  • Research Opportunities: Ongoing research is focused on understanding how compounds like this can be optimized to enhance their efficacy and reduce side effects, indicating its potential in drug design and development.

As scientists continue to study 2-(4-chlorophenyl)-2-(dimethylamino)acetonitrile, they uncover new pathways and mechanisms that could lead to innovative treatments in pharmaceuticals. The ongoing exploration emphasizes the compound's role as a promising candidate in the quest for effective medicinal therapies.

Synonyms
15190-08-6
2-(4-chlorophenyl)-2-(dimethylamino)acetonitrile
(4-Chlorophenyl)(dimethylamino)acetonitrile
4-Chloro-alpha-(dimethylamino)benzeneacetonitrile
MFCD01672927
BRN 2722922
alpha-Dimethylamino-4-chlorophenylacetonitrile
2-(p-Chlorophenyl)-2-(dimethylamino)acetonitrile
ACETONITRILE, (p-CHLOROPHENYL)(DIMETHYLAMINO)-
ACETONITRILE,(P-CHLOROPHENYL)(DIMETHYLAMINO)-
SCHEMBL9493695
DTXSID30934364
QAA19008
AKOS002303358
AKOS016053302
CS-10043
CS-0206450
ST50330287
4-Chloro-|A-(dimethylamino)benzeneacetonitrile
EN300-266071
G19203
2-(dimethylamino)-2-(4-chlorophenyl)ethanenitrile
AS-871/14031012