Skip to main content

Ketoconazole

ADVERTISEMENT
Identification
Molecular formula
C16H19ClO3
CAS number
107534-96-3
IUPAC name
[2-(4-chlorophenyl)-2-ethyl-1,3-dioxolan-4-yl]methanol
State
State

At room temperature, the compound is in a solid state.

Melting point (Celsius)
148.00
Melting point (Kelvin)
421.15
Boiling point (Celsius)
307.20
Boiling point (Kelvin)
580.35
General information
Molecular weight
354.84g/mol
Molar mass
354.8410g/mol
Density
1.0200g/cm3
Appearence

The compound is typically found as a white to off-white crystalline powder.

Comment on solubility

Solubility of [2-(4-chlorophenyl)-2-ethyl-1,3-dioxolan-4-yl]methanol

The solubility of [2-(4-chlorophenyl)-2-ethyl-1,3-dioxolan-4-yl]methanol can be described as **moderate**, influenced by its unique structural features. This compound contains both hydrophobic and hydrophilic portions, which affect its solubility in various solvents.

Key Factors Affecting Solubility:

  • Hydrophilicity: The presence of the hydroxyl group (-OH) promotes interaction with polar solvents like water, enhancing solubility.
  • Hydrophobicity: The 4-chlorophenyl and ethyl substituents contribute a hydrophobic character, potentially limiting solubility in water.
  • Solvent Compatibility: This compound may exhibit better solubility in organic solvents such as ethanol and acetone compared to aqueous solutions.

It is crucial to consider that solubility can be further affected by factors such as temperature, pH, and the presence of other solutes in the solution. As a result, assessing solubility experimentally remains vital for practical applications.

In general, compounds with both polar and nonpolar characteristics often show varying solubility trends, illustrating the principle that "like dissolves like." Therefore, understanding the balance of these factors is essential when predicting the solubility of [2-(4-chlorophenyl)-2-ethyl-1,3-dioxolan-4-yl]methanol.

Interesting facts

Facts About [2-(4-chlorophenyl)-2-ethyl-1,3-dioxolan-4-yl]methanol

[2-(4-chlorophenyl)-2-ethyl-1,3-dioxolan-4-yl]methanol is a fascinating compound that intersects various fields of chemistry, particularly organic synthesis and medicinal chemistry. Here are some interesting insights about this compound:

  • Chemical Structure: This compound features a dioxolane ring, which is known for its unique five-membered cyclic ether structure. The incorporation of a chlorophenyl group provides additional reactivity and interesting properties.
  • Applications: Compounds with similar structures are often explored for medicinal purposes, serving as potential scaffolds for drug development. They may exhibit biological activities that are beneficial in pharmacology.
  • Chirality: The presence of asymmetric centers in the structure suggests that enantiomers could exist, leading to the exploration of different stereochemical properties and their biological implications.
  • Reaction Chemistry: The methanol group can participate in various reaction mechanisms, such as nucleophilic substitutions, making this compound versatile in organic synthesis.

The study of [2-(4-chlorophenyl)-2-ethyl-1,3-dioxolan-4-yl]methanol is crucial for both theoretical and practical applications in chemical research. As a chemist, understanding the nuances of such compounds can pave the way for innovative drug design and synthesis.

Overall, this compound represents not only a specific molecular composition but also an exciting entry point into deeper discussions about chemical reactivity and potential applications in the real world.

Synonyms
K 171
2208-27-7
2-(p-Chlorophenyl)-2-ethyl-1,3-dioxolane-4-methanol
1,3-DIOXOLANE-4-METHANOL, 2-(p-CHLOROPHENYL)-2-ETHYL-
2-Aethyl-2-p-chlorphenyl-4-hydroxymethyl-1,3-dioxolan [German]
2-Aethyl-2-p-chlorphenyl-4-hydroxymethyl-1,3-dioxolan
[2-(4-chlorophenyl)-2-ethyl-1,3-dioxolan-4-yl]methanol
DTXSID30944706