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Paracetamol

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Identification
Molecular formula
C8H9NO2Cl
CAS number
103-90-2
IUPAC name
2-(4-chlorophenyl)-2-hydroxy-acetamide
State
State
Paracetamol exists as a solid at room temperature. It is typically found in a crystalline fashion when in its purest form. In commercial use, it is also often compounded within pharmaceuticals which might alter its raw physical properties.
Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
387.00
Boiling point (Kelvin)
660.15
General information
Molecular weight
151.16g/mol
Molar mass
151.1640g/mol
Density
1.2637g/cm3
Appearence

Paracetamol appears as a white, crystalline powder. It is also available in various forms including tablets, capsules, and liquid suspensions. The substance may sometimes be package-dependent; thus, it can also be a granulated powder or incorporated into a tablet along with other inert substances to control the release properties of the active pharmaceutical ingredient.

Comment on solubility

Solubility of 2-(4-chlorophenyl)-2-hydroxy-acetamide

The solubility of 2-(4-chlorophenyl)-2-hydroxy-acetamide, often referred to in research contexts, can be quite intriguing. This compound showcases a variety of solubility characteristics depending on the solvent used:

  • In Water: It presents moderate solubility due to the presence of the hydroxyl group (−OH), which facilitates hydrogen bonding with water molecules.
  • In Organic Solvents: Typically, it exhibits better solubility in organic solvents such as ethanol or methanol. The non-polar aromatic ring enhances its interaction with hydrophobic solvents.
  • Temperature Effects: As with many compounds, an increase in temperature generally leads to increased solubility; hence, elevating the temperature might improve its dissolution in various solvents.

Notably, the solubility of a compound is influenced by its molecular structure, including:

  • Hydrophilic Functional Groups: The presence of hydroxyl groups tends to increase solubility in polar solvents.
  • Hydrophobic Regions: Conversely, the chlorophenyl moiety can hinder solubility in polar solvents, causing a delicate balance between hydrophilic and hydrophobic interactions.
  • pH Sensitivity: The solubility may also vary with changes in pH, which can affect the ionization of the amide group.

In conclusion, understanding the solubility of 2-(4-chlorophenyl)-2-hydroxy-acetamide is essential for applications in pharmaceuticals and chemical synthesis, where the choice of solvent can significantly impact its effectiveness.

Interesting facts

Interesting Facts about 2-(4-Chlorophenyl)-2-hydroxy-acetamide

2-(4-Chlorophenyl)-2-hydroxy-acetamide, a compound known for its intriguing chemical properties, belongs to a class of compounds that exhibit both medicinal and industrial relevance. Here are some fascinating aspects of this compound:

  • Pharmaceutical Potential: This compound is often studied for its use in pharmaceuticals due to its potential anti-inflammatory and analgesic effects. Compounds with similar structures have been shown to interact with biological targets, making them candidates for drug development.
  • Functional Groups: The presence of a chlorophenyl group and a hydroxyl group contributes to the compound's chemical reactivity, enhancing its ability to participate in various chemical reactions. The hydroxyl group also plays a critical role in hydrogen bonding, which can influence the compound's overall properties.
  • Mechanism of Action: Compounds like 2-(4-Chlorophenyl)-2-hydroxy-acetamide may exert their effects by modulating enzyme activity or interacting with receptor sites in the body. Understanding these interactions can help in optimizing drug efficacy and minimizing side effects.
  • Environmental Impact: Chlorinated compounds can have significant environmental implications. Their stability in chemical structures means they may persist in ecosystems, leading to ongoing research into their degradation pathways and potential toxicity.
  • Research Applications: This compound is not only limited to medicinal chemistry but also finds its application in the study of reaction mechanisms and the synthesis of more complex chemical structures, illustrating its versatility.

As scientists continue to explore the array of compounds like 2-(4-Chlorophenyl)-2-hydroxy-acetamide, it becomes clear that their importance transcends their simplistic names. In the words of a distinguished chemist, "Every compound is a doorway to understanding the intricate workings of the universe." This sentiment echoes the ongoing pursuit of knowledge that drives chemical research forward.

Synonyms
2-(p-Chlorophenyl)-2-hydroxyacetamide
Mandelamide, p-chloro-
18584-27-5
2-(4-chlorophenyl)-2-hydroxyacetamide
ACETAMIDE, 2-(p-CHLOROPHENYL)-2-HYDROXY-
NSC 25105
BRN 3129733
NSC25105
SCHEMBL5068690
SCHEMBL11210166
SCHEMBL29658554
NSC-25105
AKOS011495147