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Chlorpheniramine

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Identification
Molecular formula
C16H19ClN2O
CAS number
132-22-9
IUPAC name
2-[(4-chlorophenyl)-(2-pyridyl)methoxy]-N,N-dimethyl-ethanamine
State
State

At room temperature, chlorpheniramine is stable and exists in a solid state, usually as a crystalline powder. It is typically administered orally in tablet or liquid form.

Melting point (Celsius)
61.00
Melting point (Kelvin)
334.15
Boiling point (Celsius)
384.70
Boiling point (Kelvin)
657.90
General information
Molecular weight
274.79g/mol
Molar mass
274.7880g/mol
Density
1.3000g/cm3
Appearence

Chlorpheniramine typically appears as a white crystalline powder. It is often found in its maleate salt form for pharmaceutical use, which gives it a crystalline characteristic. The compound is not hygroscopic and has a neutral to slightly bitter taste.

Comment on solubility

Solubility of 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]-N,N-dimethyl-ethanamine

The solubility of the compound 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]-N,N-dimethyl-ethanamine, with the chemical formula C16H19ClN2O, can be quite complex due to its unique molecular structure. Understanding the solubility characteristics is crucial for practical applications. Here are some key points to consider:

  • Polarity: This compound has both polar and nonpolar characteristics due to the presence of the chlorophenyl and pyridyl groups. This dual nature affects its solubility behavior in solvents.
  • Solvent Compatibility:
    • Water: The solubility in water may be limited due to the hydrophobic parts of the molecule.
    • Organic Solvents: It is likely to be more soluble in organic solvents like ethanol and DMSO due to similar polarities.
  • Temperature Effects: Solubility can also vary with temperature. Increased temperatures usually enhance solubility, making it important for laboratory considerations.
  • pH Influence: The presence of the nitrogen atoms can cause changes in solubility with varying pH levels. In acidic or basic conditions, the solubility may be altered due to protonation or deprotonation.

In conclusion, while the solubility of 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]-N,N-dimethyl-ethanamine in water may be low, it is expected to exhibit better solubility in organic solvents. Understanding these nuances is key for effective usage in chemical applications.

Interesting facts

Interesting Facts about 2-[(4-chlorophenyl)-(2-pyridyl)methoxy]-N,N-dimethyl-ethanamine

This compound, which can be referred to as a N,N-dimethyl substituted amine, is of great interest in the field of medicinal chemistry due to its potential pharmacological properties. Its unique structure allows it to engage with biological systems in innovative ways. Here are some fascinating insights:

  • Structural Components: The compound contains a chlorobenzene ring and a pyridine moiety. These aromatic systems contribute to its lipophilicity and influence interaction with various biological targets.
  • Therapeutic Potential: Research indicates that compounds containing similar structural features may exhibit significant activity against various diseases, including cancer, making this compound a candidate for further investigation.
  • Mechanism of Action: Its ability to act as a receptor modulator can be attributed to the presence of the dimethylamine group, which enhances its binding affinity to target sites.
  • Multi-Functional Nature: The presence of both chlorophenyl and pyridyl groups suggests potential for multi-target activity. This multifunctionality is key in developing new therapies that address complex diseases.
  • Environmental Considerations: As with many chlorinated compounds, it is essential to understand the environmental impact, including persistence and bioaccumulation, which may arise from its use.

As a scientist or student exploring this compound, it is crucial to highlight not just its chemical properties but also its implications in the field of drug development. The exploration of its biological effects can lead to significant advances in medicinal chemistry, enhancing our understanding of how to design effective therapeutic agents.

Synonyms
carbinoxamine
486-16-8
Paracarbinoxamine
Carbinoxamina
Allergefon
Carbinoxaminum
Paracarinoxamine
Carbinoxamine base
2-((4-Chlorophenyl)(pyridin-2-yl)methoxy)-N,N-dimethylethanamine
(+-)-Carbinoxamine
McN-R 73Z
Carbinoxaminum [INN-Latin]
Carbinoxamina [INN-Spanish]
2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine
EINECS 207-628-6
BRN 0250475
CHEBI:3398
Carbinoxamine (INN)
UNII-982A7M02H5
(+/-)-carbinoxamine
Carbinoxamine-d6 Maleate Salt
N,N-Dimethyl-2-(p-chloro-alpha-(2-pyridyl)benzyloxy)ethylamine
982A7M02H5
2-[(4-chlorophenyl)-pyridin-2-ylmethoxy]-N,N-dimethylethanamine
Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-
Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-
DTXSID4022737
5-21-03-00492 (Beilstein Handbook Reference)
Palgic
Pyridine, 2-(p-chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)-
( inverted exclamation markA)-Carbinoxamine
{2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine maleate
2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine
CARBINOXAMINE [INN]
Carbinoxaminum (INN-Latin)
Carbinoxamina (INN-Spanish)
Carbinoxamine [INN:BAN]
2-(p-Chloro-.alpha.-(2-(dimethylamino)ethoxy)benzyl)pyridine
Carbinoxamine; McN-R 73Z; Paracarbinoxamine; Paracarinoxamine
{2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine
{2-[(4-Chloro-phenyl)-pyridin-2-yl-methoxy]-ethyl}-dimethyl-amine
NCGC00166141-01
Carbinoxamin
(2-((4-Chloro-phenyl)-pyridin-2-yl-methoxy)-ethyl)-dimethyl-amine
Ethanamine, 2-[(4-chlorophenyl)-2-pyridinylmethoxy]-N,N-dimethyl-, (-)-
()-Carbinoxamine
Rondec (Salt/Mix)
Clistin (Salt/Mix)
Ziriton (Salt/Mix)
2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]-N,N-dimethylethanamine maleate
{2-[(4-Chlorophenyl)-2-pyridylmethoxy]ethyl}dimethylamine
Spectrum_000100
Prestwick0_000801
Prestwick1_000801
Prestwick2_000801
Prestwick3_000801
Spectrum2_001127
Spectrum3_000327
Spectrum4_000264
Spectrum5_000700
CARBINOXAMINE [MI]
(.+/-.)-Carbinoxamine
CHEMBL864
SCHEMBL5070
Oprea1_764868
BSPBio_000661
BSPBio_001933
CARBINOXAMINE [VANDF]
KBioGR_000728
KBioSS_000520
DivK1c_000819
SPBio_000993
SPBio_002582
2-[(4-Chlorophenyl)(2-pyridinyl)methoxy]-N,N-dimethylethanamine #
CARBINOXAMINE [WHO-DD]
BPBio1_000729
DTXCID302737
GTPL7139
BDBM81464
KBio1_000819
KBio2_000520
KBio2_003088
KBio2_005656
KBio3_001153
Carbinoxamine maleate (Salt/Mix)
R06AA08
NINDS_000819
2-[(4-chlorophenyl)-(2-pyridyl)methoxy]-N,N-dimethyl-ethanamine
ALBB-023749
HY-B1589
NSC_2564
2-{[(4-chlorophenyl)(pyridin-2-yl)methyl]oxy}-N,N-dimethylethanamine
AKOS003334261
AKOS016843886
AC-5507
DB00748
SB82406
IDI1_000819
NCGC00166141-02
NCGC00166141-03
NCGC00166141-04
CAS_486-16-8
SBI-0051304.P003
AB00053430
CS-0013488
NS00009224
C06871
D07617
EN300-755282
AB00053430_12
L000924
Q3728177
BRD-A29426959-050-05-8
BRD-A29426959-050-07-4
BRD-A29426959-050-13-2
2-[(4-chlorophenyl)-pyridin-2-yl-methoxy]-N,N-dimethyl-ethanamine
Pyridine, 2-[p-chloro-.alpha.-[2-(dimethylamino)ethoxy]benzyl]-
2-[(4-chlorophenyl)-(2-pyridyl)methoxy]ethyl-dimethyl-amine;fumaric acid
207-628-6