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2-(4-chlorophenyl)-3-methylbutane-2,3-diol

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Identification
Molecular formula
C11H15ClO2
CAS number
2216-51-5
IUPAC name
2-(4-chlorophenyl)-3-methyl-butane-2,3-diol
State
State

At room temperature, this compound is typically a solid. It is not very volatile and tends to maintain its solid state unless heat is applied.

Melting point (Celsius)
63.00
Melting point (Kelvin)
336.20
Boiling point (Celsius)
317.10
Boiling point (Kelvin)
590.30
General information
Molecular weight
202.67g/mol
Molar mass
202.6680g/mol
Density
0.9835g/cm3
Appearence

The compound is typically found as a crystalline solid. The appearance is colorless to a pale yellow, often depending on the specific purity and exposure to environmental factors. The solid form may also exhibit a shiny exterior, reflective of crystalline materials.

Comment on solubility

Solubility of 2-(4-chlorophenyl)-3-methyl-butane-2,3-diol

The solubility of the compound 2-(4-chlorophenyl)-3-methyl-butane-2,3-diol can be influenced by several factors, primarily due to its chemical structure and functional groups. This compound is expected to exhibit properties derived from its hydrophilic and hydrophobic segments, which leads to interesting solubility behavior.

Factors Influencing Solubility:

  • Polarity: The presence of hydroxyl (-OH) groups generally increases the polarity of the molecule, enhancing solubility in polar solvents such as water.
  • Hydrophobic Interactions: The phenyl and alkyl groups contribute hydrophobic characteristics, which may reduce solubility in water but increase solubility in non-polar organic solvents.
  • Temperature: Solubility can vary with temperature; typically, higher temperatures will lead to increased solubility.

In summary, while 2-(4-chlorophenyl)-3-methyl-butane-2,3-diol may show reasonable solubility in polar solvents due to its hydroxyl groups, its overall solubility profile will also depend on the medium in which it is being dissolved. For practical applications, it may be vital to conduct specific solubility tests to determine the exact behavior of this compound in various solvents.

Interesting facts

Interesting Facts about 2-(4-chlorophenyl)-3-methyl-butane-2,3-diol

The compound 2-(4-chlorophenyl)-3-methyl-butane-2,3-diol is a fascinating example of a chiral molecule, which means it has non-superimposable mirror images, much like human hands. These two forms—known as enantiomers—can exhibit very different biological activities. This compound's unique structure enhances its potential in pharmaceutical applications.

Pharmaceutical Significance

Compounds like this one are of great interest in the field of medicinal chemistry due to their ability to modulate biological systems. Here are some key points:

  • Structure-Activity Relationship (SAR): Understanding how changes in the chemical structure affect biological activity is crucial in drug design.
  • Chirality: The specific three-dimensional arrangement of atoms can influence how well a drug interacts with its target. Hence, one enantiomer may be therapeutic, while the other could be inactive or even harmful.
  • 4-Chlorophenyl Group: This group can significantly enhance the compound's lipophilicity, which may improve its absorption and distribution in biological systems.

Application and Research

Research into compounds like 2-(4-chlorophenyl)-3-methyl-butane-2,3-diol is essential for several reasons:

  • Potential Therapeutics: Chirality can lead to promising leads for drugs targeting specific pathways, such as anti-inflammatories or analgesics.
  • Environmental Studies: Understanding the behavior of such compounds in the environment can aid in predicting their impact and degradation.

In conclusion, 2-(4-chlorophenyl)-3-methyl-butane-2,3-diol represents a rich field of study where chemistry meets biology. Its unique characteristics and potential applications make it a subject of ongoing research and intrigue in the scientific community.

Synonyms
Phenaglycodol
79-93-6
Acalmid
Felixyn
Acalo
Alterton
Sinforil
Stesil
Ultran
Fenaglicodolo
Pausital
Phenglykodol
Sedapsin
Atadiol
Remin
Fenaglicodol
Fenaglycodol
Phenaglycodolum
USAF EL-44
2-(4-chlorophenyl)-3-methylbutane-2,3-diol
Phenylglycodol
Fenaglycodol [Czech]
2,3-Butanediol, 2-(4-chlorophenyl)-3-methyl-
ENT 15,208
Phenaglycodol [INN:BAN]
Fenaglicodol [INN-Spanish]
Phenaglycodolum [INN-Latin]
2-p-Chlorophenyl-3-methyl-2,3-butanediol
2-(4-Chlorophenyl)-3-methyl-2,3-butanediol
2,3-BUTANEDIOL, 2-(p-CHLOROPHENYL)-3-METHYL-
NSC 169451
B586
UNII-LMQ31KU50K
EINECS 201-235-3
LMQ31KU50K
NSC-63894
NSC-169451
BRN 2209509
2-(p-Chlorophenyl)-3-methyl-2,3-butanediol
PHENAGLYCODOL [INN]
PHENAGLYCODOL [WHO-DD]
DTXSID6023444
4-06-00-06040 (Beilstein Handbook Reference)
NSC 63894; Sinforil; Stesil; Ultran
Fenaglicodol (INN-Spanish)
Phenaglycodolum (INN-Latin)
2,3-Butanediol, 2-(4-chlorophenyl)-3-methyl- (9CI)
(+/-)-2-(P-CHLOROPHENYL)-3-METHYL-2,3-BUTANEDIOL
WLN: QX1&1&XQ1&R DG
2, 2-(p-chlorophenyl)-3-methyl-
2, 2-(4-chlorophenyl)-3-methyl-
NCIOpen2_002720
SCHEMBL259155
DTXCID903444
CHEMBL2105293
CHEBI:134889
AAA07993
NSC63894
NSC169451
AKOS028110222
DA-56788
HY-105845
CS-0026769
NS00038058
G82758
2,3-Butanediol, 2-(4-chlorophenyl)-3-methyl-(9CI)
Q19598565
201-235-3