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Letrozole

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Identification
Molecular formula
C17H11ClN2O
CAS number
112809-51-5
IUPAC name
2-(4-chlorophenyl)-6-phenyl-1H-1,3,5-triazin-4-one
State
State

Letrozole is a solid at room temperature. It is stable under normal conditions and typically handled in its powdered form when used in pharmaceutical preparations.

Melting point (Celsius)
184.00
Melting point (Kelvin)
457.15
Boiling point (Celsius)
586.90
Boiling point (Kelvin)
860.05
General information
Molecular weight
259.12g/mol
Molar mass
259.1170g/mol
Density
1.2550g/cm3
Appearence

Letrozole appears as a white to yellowish crystalline powder. It is not hygroscopic and has a crystalline solid structure which is typical for many pharmaceutical compounds.

Comment on solubility

Solubility of 2-(4-chlorophenyl)-6-phenyl-1H-1,3,5-triazin-4-one

The solubility of 2-(4-chlorophenyl)-6-phenyl-1H-1,3,5-triazin-4-one can be characterized by several key factors:

  • Polarity: The presence of multiple aromatic rings and the chlorine substituent suggests that this compound may exhibit moderate polarity. This can influence its solubility in organic solvents.
  • Solvent Compatibility: It is likely to be soluble in organic solvents such as Chloroform, DMSO, and Acetonitrile, which are well-suited for polar-aromatic compounds.
  • Water Solubility: Due to its hydrophobic components, this triazine derivative is expected to have limited solubility in water, aligning with many organic compounds of similar structure.

Overall, the solubility profile indicates that while it may not readily dissolve in aqueous solutions, its compatibility with organic solvents allows for versatility in various chemical environments.

In summary, the solubility of this compound highlights the balance between its polar and non-polar characteristics. This balance is essential for its applications and interactions within chemical processes.

Interesting facts

Interesting Facts about 2-(4-Chlorophenyl)-6-phenyl-1H-1,3,5-triazin-4-one

2-(4-Chlorophenyl)-6-phenyl-1H-1,3,5-triazin-4-one is a fascinating compound known for its diverse applications, particularly in the fields of pharmaceuticals and agrochemicals. Here are some key insights into this intriguing compound:

  • Structural Uniqueness: The structure of this compound features a triazine ring, which is a six-membered aromatic ring containing three nitrogen atoms. This unique arrangement contributes to its chemical reactivity and potential biological activity.
  • Role in Drug Development: Compounds like 2-(4-chlorophenyl)-6-phenyl-1H-1,3,5-triazin-4-one often serve as intermediates in the synthesis of pharmaceuticals. The presence of the chlorophenyl and phenyl groups may enhance the efficacy and selectivity of drugs targeting specific biological pathways.
  • Applications in Agriculture: Beyond its medicinal properties, this compound’s derivatives can be explored for use in pesticides and herbicides. The triazine structure has been widely investigated for its ability to inhibit specific enzymes in plants, making it a substance of interest in agrochemical research.
  • Research Significance: Scientists continue to study compounds like this for their potential as anti-cancer agents, anti-inflammatory agents, and more. The combination of different groups within the molecule may yield novel properties, encouraging ongoing research.
  • Environmental Considerations: As with many chemical compounds, the environmental impact of triazine derivatives is a topic of study. Their persistence in the ecosystem necessitates exploration into their degradation and toxicity to ensure safe agricultural practices.

In conclusion, 2-(4-chlorophenyl)-6-phenyl-1H-1,3,5-triazin-4-one exemplifies the intricate relationship between molecular structure and functional properties, making it a subject of great interest in both scientific research and practical applications.