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4-Chlorophenylacetic acid

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Identification
Molecular formula
C8H7ClO2
CAS number
1878-66-6
IUPAC name
2-(4-chlorophenyl)acetic acid
State
State

At room temperature, 4-Chlorophenylacetic acid is typically in a solid state.

Melting point (Celsius)
68.00
Melting point (Kelvin)
341.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
170.59g/mol
Molar mass
170.5750g/mol
Density
1.3520g/cm3
Appearence

4-Chlorophenylacetic acid appears as a white crystalline solid. It has a characteristic odor and is a common reagent in organic synthesis.

Comment on solubility

Solubility of 2-(4-chlorophenyl)acetic acid

2-(4-chlorophenyl)acetic acid, a compound with interesting chemical properties, exhibits specific solubility characteristics. The solubility of this compound can be influenced by various factors, which are crucial to understanding its behavior in different environments:

  • Water Solubility: This compound is considered to have limited solubility in water. Due to its aromatic structure, the hydrophobic character can hinder its ability to dissolve readily.
  • Organic Solvents: It shows better solubility in organic solvents, where it can achieve higher concentrations. Common organic solvents like ethanol or acetone can effectively dissolve this compound.
  • Temperature Effects: As with many organic acids, solubility can increase with temperature. This aspect allows for more effective dissolution under heated conditions.

In practical applications, understanding the solubility of 2-(4-chlorophenyl)acetic acid is essential for its use in:

  • Pharmaceutical applications, where its solubility profile can affect bioavailability.
  • Synthesis processes that require precise conditions for effective reaction.
  • Environmental studies, where solubility influences the distribution of the compound in soil and water.

In summary, while 2-(4-chlorophenyl)acetic acid presents challenges in aqueous environments due to its limited solubility, it remains versatile in organic media, showcasing the importance of understanding solvent interactions in chemical applications.

Interesting facts

Interesting Facts about 2-(4-Chlorophenyl)acetic Acid

2-(4-Chlorophenyl)acetic acid, a fascinating compound commonly used in the pharmaceutical industry, is primarily recognized for its role as an important intermediate in the synthesis of various drugs. Here are some notable points regarding this compound:

  • Pharmaceutical Relevance: This compound is an essential building block in the production of several medications, particularly those aimed at treating inflammation and pain.
  • Mechanism of Action: It exhibits its pharmacological effects by inhibiting certain pathways that contribute to pain and inflammation, showcasing the significance of its structure in medicinal chemistry.
  • Research Potential: Scientists are continuously exploring modifications of the 2-(4-chlorophenyl)acetic acid structure to enhance efficacy and reduce potential side effects, opening doors for novel therapies.
  • Environmental Considerations: Due to its chlorinated nature, there is ongoing research into its environmental impact and degradation products, highlighting the importance of assessing the ecological effects of pharmaceutical compounds.

This compound serves not only as a pivotal agent in therapeutic applications but also reflects the intricate relationship between chemistry, medicine, and environmental science. As such, 2-(4-chlorophenyl)acetic acid stands as a prime example of how chemical properties can lead to meaningful advancements in healthcare.

Synonyms
4-Chlorophenylacetic acid
1878-66-6
2-(4-chlorophenyl)acetic acid
Benzeneacetic acid, 4-chloro-
P-CHLOROPHENYLACETIC ACID
(4-Chlorophenyl)acetic acid
4-Chlorobenzeneacetic acid
(p-Chlorophenyl)acetic acid
Acetic acid, (p-chlorophenyl)-
LLQ6PU28WR
EINECS 217-521-6
NSC 14285
BRN 1072816
CCRIS 8622
NSC-14285
Acetic acid, p-chlorophenyl-
DTXSID7062031
CHEBI:30749
DTXCID8035926
cdpkjzjvthsesz-uhfffaoysa-n
inchi=1/c8h7clo2/c9-7-3-1-6(2-4-7)5-8(10)11/h1-4h,5h2,(h,10,11
2-(p-Chlorophenyl)acetic acid
4-Chlorophenyl acetic acid
MFCD00004344
4-CHLOROPHENYLACETATE
(4-chloro-phenyl)-acetic acid
p-chlorophenyl acetic acid
4chlorophenylacetic acid
4-chiorophenylacetic acid
UNII-LLQ6PU28WR
4-chlorophenyl-acetic acid
bmse000395
para-chlorophenyl acetic acid
SCHEMBL75665
(p-Chloro-phenyl)acetic acid
(4-chlorophenyl)-acetic acid
2-(4-chlorophenyl)aceticacid
Acetic acid, 4-chlorophenyl-
2-(4-chlorophenyl) acetic acid
2-(4-chlorophenyl)-acetic acid
BDBM16427
acetic acid, 2-(4-chlorophenyl)-
BCP21026
NSC14285
STK498738
AKOS000119602
AC-2907
BS-3929
CS-W010778
FC37735
HY-W010062
DA-60345
PD158271
NS00015320
EN300-20301
C03077
D70527
4-Chlorophenylacetic acid, ReagentPlus(R), 99%
AQ-917/41718247
Q27104143
F0001-0673
Z104477676
4-Chlorophenylacetic acid, Vetec(TM) reagent grade, 98%
67EF95C4-F494-4586-880F-393BCD1F8F3D