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Metformin

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Identification
Molecular formula
C7H13ClN2
CAS number
120202-66-6
IUPAC name
2-[(4-chlorophenyl)methyl]-1-(diaminomethylene)guanidine
State
State

Metformin is typically found in a solid state at room temperature. It is often provided in tablet form as it is commonly used as an oral diabetes medication.

Melting point (Celsius)
223.00
Melting point (Kelvin)
496.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
141.15g/mol
Molar mass
141.1540g/mol
Density
1.4400g/cm3
Appearence

Metformin is usually encountered as a white to off-white crystalline solid that is odorless and hygroscopic.

Comment on solubility

Solubility of 2-[(4-chlorophenyl)methyl]-1-(diaminomethylene)guanidine

The solubility of 2-[(4-chlorophenyl)methyl]-1-(diaminomethylene)guanidine can be influenced by several factors due to its unique structure. Here are some key points to consider:

  • Polarity: The presence of the guanidine group suggests a degree of polar character, which often enhances solubility in polar solvents, such as water.
  • Hydrogen Bonding: This compound can form hydrogen bonds due to the amine groups, potentially improving solubility in protic solvents.
  • Aromatic Interactions: The 4-chlorophenyl group may interact through π-π stacking or hydrophobic effects in organic solvents, affecting solubility parameters.

However, it is crucial to note that the overall solubility will vary depending on solvent composition, temperature, and the presence of other solutes. In general, compounds with strong hydrogen bonding capabilities tend to be more soluble in aqueous environments. As with many organic compounds, empirical data is the best way to assess the specific solubility characteristics of this guanidine derivative.

In conclusion, while predicting solubility can be complex, the structural features of 2-[(4-chlorophenyl)methyl]-1-(diaminomethylene)guanidine suggest that it could have reasonable solubility in polar solvents, encouraging further investigation.

Interesting facts

Interesting Facts About 2-[(4-chlorophenyl)methyl]-1-(diaminomethylene)guanidine

This compound, known for its complex structure, possesses a unique interplay of functional groups that contribute to its intriguing chemical behavior. Here are some noteworthy aspects of 2-[(4-chlorophenyl)methyl]-1-(diaminomethylene)guanidine:

  • Pharmaceutical Importance: This compound may have applications in drug development, particularly in the field of anti-cancer and anti-inflammatory medications. The presence of the guanidine moiety enhances its biological activity.
  • Mechanistic Insights: Its structure allows for various modes of interaction at the molecular level, offering insights into enzyme inhibition and receptor binding mechanisms.
  • Biological Activity: The incorporation of a chlorophenyl group is significant; chlorinated aromatic compounds often exhibit increased biological activity, making this compound a point of interest for medicinal chemists.
  • Research Potential: Given its structural diversity, this compound can serve as a valuable lead in the synthesis of various derivatives, prompting ongoing research into its pharmacological properties.

In summary, 2-[(4-chlorophenyl)methyl]-1-(diaminomethylene)guanidine embodies a rich tapestry of possibilities that intrigue both scientists and researchers alike. Its multifaceted nature continues to inspire studies aimed at discovering new applications and mechanisms. As a bridge between organic chemistry and medicinal research, this compound represents the exciting potential of synthetic chemistry in contributing to advancements in healthcare.

Synonyms
SCHEMBL1040794
CHEMBL4117356
AKOS017268682