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Papaverine hydrochloride

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Identification
Molecular formula
C20H21ClNO4
CAS number
61-25-6
IUPAC name
2-[(4-chlorophenyl)methyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;4-hydroxy-4-oxo-but-2-enoate
State
State

At room temperature, Papaverine hydrochloride is a solid. It is primarily encountered in its hydrochloride salt form for stability and ease of handling in pharmaceutical applications.

Melting point (Celsius)
147.80
Melting point (Kelvin)
421.00
Boiling point (Celsius)
357.80
Boiling point (Kelvin)
631.00
General information
Molecular weight
375.85g/mol
Molar mass
295.7810g/mol
Density
1.2800g/cm3
Appearence

Papaverine hydrochloride, in its crystalline form, appears as a white or off-white crystalline powder. It is known for its purity and has a relatively consistent texture. In solution, it can appear colorless to slightly yellowish depending on concentration and conditions.

Comment on solubility

Solubility of 2-[(4-chlorophenyl)methyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;4-hydroxy-4-oxo-but-2-enoate

The solubility of the compound 2-[(4-chlorophenyl)methyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;4-hydroxy-4-oxo-but-2-enoate can be complex due to its unique and intricate structure.

Key points regarding its solubility include:

  • Polar and Non-Polar Characteristics: The presence of both polar and non-polar groups in this compound can lead to variability in solubility depending on the solvent used. The 4-chlorophenyl group tends to impart non-polar characteristics, while the dimethoxy and tetrahydroisoquinoline moieties introduce polar aspects.
  • Solvent Dependency: The compound may be soluble in organic solvents, such as ethanol or methanol, but might exhibit limited solubility in water due to its hydrophobic regions.
  • pH Sensitivity: As the compound contains cationic and anionic sections, its solubility could also vary with pH. Under highly acidic or basic conditions, solubility may increase due to protonation or deprotonation of functional groups.

In summary, the solubility of this compound is influenced by its structural features and the nature of the solvent. Experimentation with various solvents will provide a clearer understanding of how this compound behaves in solution. As with many organic compounds, the phrase "like dissolves like" holds true: non-polar solvents should dissolve the non-polar portions effectively, while polar solvents benefit the polar regions.

Interesting facts

Interesting Facts about 2-[(4-chlorophenyl)methyl]-6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium;4-hydroxy-4-oxo-but-2-enoate

This compound, often referred to as a complex heterocyclic structure, showcases the fascinating intersection of organic chemistry and medicinal applications. Its unique properties and structure have piqued the interest of researchers for several reasons:

  • Bioactive Potential: The presence of the tetrahydroisoquinoline core is significant in pharmaceutical chemistry. Compounds with this scaffold have been associated with a range of biological activities, including neuroprotective and antitumor properties.
  • Chirality: The center of chirality in this molecule creates enantiomers that can exhibit different biological activities. This aspect emphasizes the importance of stereochemistry in drug design.
  • Substituent Influence: The 4-chlorophenyl substituent can enhance the lipophilicity of the compound, leading to better membrane permeability. Such modifications are essential in optimizing pharmacokinetic properties.
  • Dual Functionality: The presence of both the isoquinoline and the 4-hydroxy-4-oxo-but-2-enoate moiety suggests potential for dual-targeting in therapeutic applications, making it an interesting compound in the field of drug discovery.
  • Synthetic Routes: Chemists are interested in the synthetic methodologies to construct such a complex compound, as these routes can lead to the development of new synthetic techniques and catalytic processes.

"Exploring the depths of heterocyclic chemistry can lead to the unveiling of novel therapeutic agents." This compound stands as a testament to the innovative spirit within the field, inspiring chemists and pharmacologists alike to explore its potential.

As research continues, the future may hold exciting discoveries linked to this compound, further illustrating the vast possibilities encapsulated within synthetic organic chemistry.