Skip to main content

Loratadine

ADVERTISEMENT
Identification
Molecular formula
C22H23ClN2O2
CAS number
79794-75-5
IUPAC name
2-[(4-chlorophenyl)methyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline
State
State

Loratadine is typically found in a solid state at room temperature.

Melting point (Celsius)
134.00
Melting point (Kelvin)
407.15
Boiling point (Celsius)
528.50
Boiling point (Kelvin)
801.70
General information
Molecular weight
382.88g/mol
Molar mass
382.8810g/mol
Density
1.5343g/cm3
Appearence

Loratadine is a white to off-white crystalline powder. It is freely soluble in acetone, soluble in methanol, and insoluble in water.

Comment on solubility

Solubility of 2-[(4-chlorophenyl)methyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline

The solubility of 2-[(4-chlorophenyl)methyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline can be influenced by various factors such as polarity, temperature, and the solvent system used. Understanding its solubility can help in predicting its behavior in different environments:

  • Polarity: The presence of methoxy groups can significantly alter the overall polarity of the molecule. As these groups are electron-donating, they tend to increase solubility in polar solvents.
  • Temperature: Increased temperature often enhances solubility, which is essential when considering formulations and reactions involving this compound.
  • Solvent Effect: This compound may exhibit enhanced solubility in organic solvents such as ethanol and DMSO, while showing limited solubility in water.

It is intriguing to note that the solubility of a compound can be both a physical and chemical property, influencing its biological activity and applications in pharmaceuticals. As a general guideline, compounds with similar functional groups tend to dissolve in similar solvent types, following the principle of “like dissolves like.” Understanding these principles can aid chemists in effectively utilizing this compound in various applications.

Interesting facts

Interesting Facts about 2-[(4-chlorophenyl)methyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline

This intriguing compound is a member of the isoquinoline family, which is known for its diverse range of biological activities and potential therapeutic applications. Isoquinolines are often explored in medicinal chemistry due to their ability to interact with various biological targets. Here are some fascinating insights about this particular compound:

  • Pharmacological Potential: Compounds containing isoquinoline structures have been studied for their antitumor, antimicrobial, and antidepressant properties, making them of great interest in the field of drug discovery.
  • Structure-Activity Relationship: The presence of the 4-chlorophenyl and dimethoxy substituents can significantly influence the compound's biological activity, illustrating the importance of molecular modifications in the design of pharmaceuticals.
  • Synthetic Challenges: The synthesis of such complex organic molecules requires meticulous attention to detail and advanced techniques in organic chemistry, including multi-step synthesis and possibly the use of protecting groups.
  • Natural Occurrence: Isoquinolines can be found in various plants and have been noted for their roles in traditional medicine. Studying synthetic analogs can lead to the discovery of new natural products or enhance the properties of existing ones.

Understanding compounds like this one not only broadens our knowledge of organic chemistry but also sheds light on potential new therapies for human health. As noted by one researcher, "The subtle changes in molecular structure can lead to profound differences in biological function." This emphasizes the need for thoughtful exploration and study of compounds in medicinal chemistry.

In summary, the study of 2-[(4-chlorophenyl)methyl]-6,7-dimethoxy-1-methyl-3,4-dihydro-1H-isoquinoline exemplifies the delicate balance between structure, activity, and synthesis in the quest to develop new therapeutic agents.