Skip to main content

Iodoxamic acid

ADVERTISEMENT
Identification
Molecular formula
C14H16I2O3
CAS number
65224-63-7
IUPAC name
2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]cyclohexanecarboxylic acid
State
State

Iodoxamic acid is in a solid state at room temperature, generally existing as a crystalline powder.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
410.00
Boiling point (Kelvin)
683.15
General information
Molecular weight
571.96g/mol
Molar mass
571.9560g/mol
Density
2.0000g/cm3
Appearence

Iodoxamic acid appears as a white to off-white crystalline powder. It is slightly soluble in water and more soluble in solvents like methanol and dimethyl sulfoxide (DMSO).

Comment on solubility

Solubility of 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]cyclohexanecarboxylic acid

The solubility of 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]cyclohexanecarboxylic acid can be assessed through both its chemical structure and the functional groups present. This compound contains several key features that influence its solubility:

  • Hydroxyl Groups: The presence of a hydroxy group (–OH) typically enhances solubility in polar solvents due to hydrogen bonding.
  • Iodine Atoms: The attached iodine atoms can introduce steric hindrance and influence the polarity, potentially reducing solubility in water.
  • Carboxylic Acid Group: The carboxylic acid (–COOH) group can contribute to solubility in aqueous solutions by ionizing to form carboxylate anions, which are more soluble.

However, the overall solubility of this compound is likely to be moderate to low in water due to the bulky nature of the cyclohexane ring and the presence of multiple iodine atoms, which could lead to less favorable interactions in polar solvents. As a result:

  • In polar solvents such as water, the solubility may be limited.
  • In organic solvents like ethanol or dimethyl sulfoxide (DMSO), solubility might be enhanced.

In conclusion, the solubility of 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]cyclohexanecarboxylic acid reflects a balance between its polar functional groups and the relatively non-polar hydrocarbon structure, making it an interesting compound for studies regarding solubility profiles in various solvents.

Interesting facts

Interesting Facts about 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]cyclohexanecarboxylic acid

This fascinating compound, known for its intricate structure, offers a variety of interesting applications and properties that are worthy of exploration:

  • Pharmaceutical Relevance: Compounds such as 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]cyclohexanecarboxylic acid often play a significant role in drug development. They may serve as potential leads in the synthesis of novel therapeutic agents due to their unique structural features.
  • Iodine Substitution: The incorporation of iodine into the molecular framework can enhance the biological activity of compounds. Iodinated phenolic compounds are known for their antimicrobial and anticancer properties.
  • Chirality: The cyclic structure of this compound suggests that it may possess chiral centers, which can lead to different enantiomers. These enantiomers may exhibit varying levels of activity in biological systems, thus making stereochemistry a crucial factor in its applications.
  • Biochemical Interactions: The hydroxyl (–OH) group within the aromatic ring is known to play a pivotal role in hydrogen bonding and can influence the compound’s interactions with biological macromolecules, such as proteins and nucleic acids.
  • Environmental Impact: Compounds with halogen atoms, particularly iodine, can undergo interesting reactions in environmental settings. The behavior of such compounds in biological systems and in the environment is a subject of ongoing research.

As a constantly evolving field, the study of this compound emphasizes the importance of interdisciplinary research that combines chemistry, biology, and pharmacology. Understanding its full potential could lead to valuable advancements in various scientific disciplines.

Synonyms
Monophen
530-77-8
2-(3,5-Diiodo-4-hydroxybenzyl)cyclohexanecarboxylic acid
BRN 3368153
UNII-01WCB47656
2-(4-Hydroxy-3,5-dijodbenzyl)cyclohexancarbonsaeure [German]
01WCB47656
2-(4-Hydroxy-3,5-diiodbenzyl)-1-cyclohexancarbonsaeure
3-10-00-00911 (Beilstein Handbook Reference)
2-(4-Hydroxy-3,5-dijodbenzyl)cyclohexancarbonsaeure
Cyclohexanecarboxylic acid, 2-(3,5-diiodo-4-hydroxybenzyl)-
2-(4-HYDROXY-3,5-DIIODOBENZYL)CYCLOHEXANECARBOXYLIC ACID
CYCLOHEXANECARBOXYLIC ACID, 2-(4-HYDROXY-3,5-DIIODOBENZYL)-
(+-)-2-(3,5-diiodo-4-hydroxybenzyl)cyclohexanecarboxylic acid
2-[(4-hydroxy-3,5-diiodophenyl)methyl]cyclohexane-1-carboxylic acid
Cyclohexanecarboxylic acid, 2-((4-hydroxy-3,5-diiodophenyl)methyl)-
(+/-)-2-(3,5-DIIODO-4-HYDROXYBENZYL)CYCLOHEXANECARBOXYLIC ACID
SCHEMBL4579456
DTXSID10967478
Q27231459