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Levothyroxine

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Identification
Molecular formula
C15H11I2NO4
CAS number
51-48-9
IUPAC name
2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]hexanoic acid
State
State

Levothyroxine is typically in a solid state at room temperature.

Melting point (Celsius)
231.00
Melting point (Kelvin)
504.15
Boiling point (Celsius)
405.70
Boiling point (Kelvin)
678.85
General information
Molecular weight
776.87g/mol
Molar mass
776.8730g/mol
Density
1.4422g/cm3
Appearence

Levothyroxine appears as a white to off-white, odorless, crystalline powder.

Comment on solubility

Solubility of 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]hexanoic acid

When discussing the solubility of 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]hexanoic acid, it is essential to consider several factors that influence its behavior in various solvents:

  • Polarity: This compound contains a hydroxyl group and a long hydrocarbon chain, which may lead to variable solubility characteristics.
  • Functional Groups: The presence of the hydroxyl group suggests that the compound could exhibit good solubility in polar solvents such as water, while the hydrophobic hexanoic acid portion may limit its overall solubility.
  • Hydrogen Bonding: The -OH group can engage in hydrogen bonding, which enhances solubility in polar solvents.
  • Temperature: As with many organic compounds, temperature can significantly affect solubility; it is recommended to test solubility at different temperatures for a more comprehensive understanding.

In conclusion, while 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]hexanoic acid is likely to have some degree of solubility in polar solvents due to the hydroxyl group and potential for hydrogen bonding, the overall solubility could be limited by its hydrophobic components. It is prudent to evaluate solubility under varying conditions and in different solvents for practical applications.

Interesting facts

Interesting Facts about 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]hexanoic acid

2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]hexanoic acid, commonly known for its role in various biochemical processes, presents fascinating characteristics that attract the attention of chemists and biologists alike. Here are some intriguing facts about this compound:

  • Biological Implications: This compound is primarily recognized for its influence on lipid metabolism, making it a subject of research in obesity and diabetes studies.
  • Structural Complexity: The presence of the diiodinated phenyl ring introduces unique interactions within biological systems, potentially affecting the compound's reactivity and function.
  • Potential Therapeutic Applications: Due to its structural features, this compound is being investigated for potential anti-inflammatory and anti-cancer properties, showcasing the versatility of halogenated compounds in medicinal chemistry.
  • Environmental Considerations: As a halogenated organic compound, the environmental impact of its synthesis and degradation is an essential aspect of its study, prompting discussions on sustainable practices in chemical synthesis.
  • Synthesis Challenges: The synthesis of 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]hexanoic acid can be challenging due to the need for selective iodination and the maintenance of the hydroxyl group, making it an interesting target for organic chemists.

Overall, the multifaceted nature of 2-[(4-hydroxy-3,5-diiodo-phenyl)methyl]hexanoic acid highlights the excitement within the field of organic chemistry and its implications in both health and environmental science:

“Chemistry is not just about substances; it is about the interactions, transformations, and implications that come with them.”

Synonyms
2-(4-Hydroxy-3,5-diiodobenzyl)hexanoic acid
17048-40-7
QJT97I8GMA
NIOSH/MW5097500
MW50975000
alpha-Butyl-3,5-diiodo-4-hydroxyhydrocinnamic acid
Hydrocinnamic acid, alpha-butyl-3,5-diiodo-4-hydroxy-
UNII-QJT97I8GMA
2-[(4-hydroxy-3,5-diiodophenyl)methyl]hexanoic acid
SCHEMBL21048106
Benzenepropanoic acid, alpha-butyl-4-hydroxy-3,5-diiodo-
DTXSID50937771
Hydrocinnamic acid, .alpha.-butyl-4-hydroxy-3,5-diiodo-
Benzenepropanoic acid, .alpha.-butyl-4-hydroxy-3,5-diiodo-
Q27287298
.ALPHA.-(4-HYDROXY-3,5-DIIODOBENZYL)CAPROIC ACID
.ALPHA.-BUTYL-4-HYDROXY-3,5-DIIODOHYDROCINNAMIC ACID
2-(4-HYDROXY-3,5-DIIODOBENZYL)HEXANOIC ACID, (+/-)-