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4-Hydroxyphenylacetonitrile

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Identification
Molecular formula
C8H7NO
CAS number
135-22-8
IUPAC name
2-(4-hydroxyphenyl)acetonitrile
State
State

The compound is typically found as a solid at room temperature, maintaining its crystalline structure under standard conditions.

Melting point (Celsius)
83.00
Melting point (Kelvin)
356.15
Boiling point (Celsius)
308.80
Boiling point (Kelvin)
581.95
General information
Molecular weight
133.15g/mol
Molar mass
133.1520g/mol
Density
1.1450g/cm3
Appearence

4-Hydroxyphenylacetonitrile appears as a white to off-white crystalline solid. Its crystalline nature means it forms well-defined geometric shapes when in solid form.

Comment on solubility

Solubility of 2-(4-hydroxyphenyl)acetonitrile

2-(4-hydroxyphenyl)acetonitrile is a compound with noteworthy solubility characteristics. Understanding its solubility can be beneficial for various applications in chemical synthesis and pharmacology. Here are some key points regarding its solubility:

  • Solvent Dependency: This compound exhibits solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), making it useful in environments where these solvents are prevalent.
  • Water Solubility: 2-(4-hydroxyphenyl)acetonitrile has limited solubility in water. This characteristic can influence its bioavailability and environmental persistence.
  • pH Influence: The presence of the hydroxyl group may lead to modifications in solubility under different pH conditions. Specifically, at higher pH levels, the compound may engage in interactions that enhance solubility.
  • Temperature Effect: As with many organic compounds, an increase in temperature typically aids in increasing the solubility of 2-(4-hydroxyphenyl)acetonitrile in solvents.

In summary, 2-(4-hydroxyphenyl)acetonitrile's solubility is affected by factors such as solvent choice, pH, and temperature. Understanding these nuances is crucial for effective utilization in both research and industrial applications.

Interesting facts

Interesting Facts about 2-(4-hydroxyphenyl)acetonitrile

2-(4-hydroxyphenyl)acetonitrile, often referred to simply as a phenolic compound, is an intriguing chemical that has garnered interest in both the fields of medicinal chemistry and materials science. Here are some fascinating aspects of this compound:

  • Versatile Applications: This compound serves as a valuable intermediate in the synthesis of various pharmaceuticals, agrochemicals, and dyes, highlighting its utility across multiple industries.
  • Biological Significance: It has been studied for its potential biological activities, including antitumor and antioxidant properties, making it a topic of interest for drug discovery.
  • Phenolic Structure: The presence of the hydroxy groups in the structure enhances reactivity and provides sites for further chemical modification, which is essential for developing new derivatives with enhanced properties.
  • Environmental Considerations: As a compound that may enter the environment through various pathways, understanding its degradation and toxicity is vital for ecological safety and regulatory compliance.
  • Research Opportunities: Given its unique structural features, 2-(4-hydroxyphenyl)acetonitrile offers numerous opportunities for research in organic synthesis and materials chemistry. Scientists are continually exploring new reaction pathways and formulation techniques to optimize its properties and applications.

In summary, 2-(4-hydroxyphenyl)acetonitrile is more than just a chemical compound; it represents a blend of chemistry, biology, and environmental science that can lead to innovative solutions and discoveries. As noted by researchers, "The study of such compounds often reveals unexpected pathways to new technological advancements." This emphasizes the importance of exploring less charted compounds in the quest for knowledge and innovation.

Synonyms
14191-95-8
4-Hydroxyphenylacetonitrile
4-Hydroxybenzyl cyanide
2-(4-hydroxyphenyl)acetonitrile
(4-Hydroxyphenyl)acetonitrile
Benzeneacetonitrile, 4-hydroxy-
4-HYDROXYBENZYLCYANIDE
4-Hydroxybenzeneacetonitrile
18Q5J224RM
NSC-76080
CHEBI:16667
DTXSID90161856
PHBC
para-hydroxybenzylcyanide
DTXCID6084347
238-046-0
p-Hydroxybenzyl cyanide
p-Hydroxyphenylacetonitrile
Acetonitrile, (p-hydroxyphenyl)-
MFCD00002383
4-Hydroxyphenylacetic acid nitrile
2-(4-hydroxyphenyl)ethanenitrile
ACETIC ACID,(4-HYDROXYPHENYL),NITRILE 4-HYDROXY-BENZYLCYANIDE
(4-hydroxy-phenyl)-acetonitrile
4-(Cyanomethyl)phenol
EINECS 238-046-0
NSC 76080
BRN 1934470
UNII-18Q5J224RM
alpha-cyano-p-cresol
para-hydroxybenzyl cyanide
bmse000441
p-hydroxy phenyl acetonitrile
4-10-00-00554 (Beilstein Handbook Reference)
SCHEMBL448467
4-(hydroxy)phenyl acetonitrile
Acetonitrile, 4-hydroxyphenyl-
orb1311045
4-Hydroxyphenylacetonitrile, 98%
HMS1786P20
NSC76080
STR01465
SBB063205
AKOS000121408
CS-W016539
FH24478
HY-W015823
PS-4572
Benzeneacetonitrile, 4-hydroxy- (9CI)
AC-10551
PD158329
SY007110
DB-028916
H0657
NS00024606
ST51045377
EN300-18729
C03766
AE-562/40164564
4-Hydroxybenzyl cyanide;4-Hydroxy-benzeneacetonitrile
Q27102019
Z90120144
7898C7A4-5D46-437F-8474-B1E83F66AFE5
InChI=1/C8H7NO/c9-6-5-7-1-3-8(10)4-2-7/h1-4,10H,5H
3AQ