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2-(4-hydroxyphenyl)guanidine

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Identification
Molecular formula
C7H9N3O
CAS number
13055-40-6
IUPAC name
2-(4-hydroxyphenyl)guanidine
State
State
At room temperature, 2-(4-hydroxyphenyl)guanidine exists in a solid state, typically appearing as a fine crystalline powder with a tendency to form agglomerates.
Melting point (Celsius)
162.00
Melting point (Kelvin)
435.15
Boiling point (Celsius)
314.00
Boiling point (Kelvin)
587.15
General information
Molecular weight
151.17g/mol
Molar mass
151.1660g/mol
Density
1.3400g/cm3
Appearence
2-(4-hydroxyphenyl)guanidine is a white crystalline solid. The compound forms elongated, flat crystals that can appear slightly off-white upon exposure to ambient conditions. Its appearance may vary slightly depending on the purity of the sample and the conditions of crystallization.
Comment on solubility

Solubility of 2-(4-hydroxyphenyl)guanidine

The solubility of 2-(4-hydroxyphenyl)guanidine is a fascinating topic, as it showcases the compound's interaction with various solvents. The solubility of this compound can be influenced by several factors:

  • Polarity: The presence of the hydroxyl group (-OH) contributes to the overall polarity of the molecule, making it more soluble in polar solvents such as water.
  • Temperature: Solubility often increases with higher temperatures. Therefore, heating the solvent may enhance the dissolution of 2-(4-hydroxyphenyl)guanidine.
  • pH level: As an organic compound with basic properties, changes in pH can affect ionization, thus impacting solubility.
  • Hydrogen Bonding: The ability to form hydrogen bonds with other molecules can also enhance solubility.

Generally, 2-(4-hydroxyphenyl)guanidine exhibits moderate solubility in water, which can be attributed to the balance between its hydrophilic (-OH group) and hydrophobic parts of the molecule. This compound's moderate solubility profile is crucial for its applications in various fields, including pharmaceuticals and materials science.

To summarize, the solubility of 2-(4-hydroxyphenyl)guanidine is an intriguing area of study, especially when considering its practical implications and the influence of external factors.

Interesting facts

Interesting Facts about 2-(4-hydroxyphenyl)guanidine

2-(4-hydroxyphenyl)guanidine is a fascinating compound that has sparked significant interest within the fields of biochemistry and medicinal chemistry. Here are a few noteworthy aspects:

  • Biological Activity: The compound is studied for its potential role as a pharmacological agent, particularly in the context of its ability to interact with biological receptors.
  • Antioxidant Properties: There is accumulating evidence suggesting that 2-(4-hydroxyphenyl)guanidine may possess antioxidant properties, which are valuable in combating oxidative stress within biological systems.
  • Research Applications: It is employed in various research studies aimed at understanding its role in cellular mechanisms, and its effect on certain biochemical pathways could pave the way for new therapeutic strategies.
  • Chemical Versatility: This compound can be modified to enhance its properties, making it an interesting target for synthetic chemists interested in developing new derivatives.
  • Structure-Activity Relationship (SAR): Investigating the relationship between its molecular structure and biological activity provides insights that could be critical for drug design and development.

In addition, the compound's structural characteristics, particularly the presence of the –OH group, play a crucial role in its biological interactions. The hydroxy group can participate in hydrogen bonding, enhancing its solubility in biological environments. As one researcher noted, "Understanding the molecular intricacies of compounds like 2-(4-hydroxyphenyl)guanidine is a fundamental stepping stone towards developing effective therapeutic agents."

Overall, 2-(4-hydroxyphenyl)guanidine exemplifies the rich interplay between structure and function in chemical compounds, making it an intriguing subject for ongoing scientific inquiry.

Synonyms
CHEMBL2323124
1-(4-Hydroxyphenyl)Guanidine Hydrochloride
1-(4-hydroxyphenyl)guanidine
Oxyphenylguanidine
14279-92-6
SCHEMBL447770
SCHEMBL4099993
SCHEMBL8191428
CHEMBL2365091
benzene, 1-guanidino-4-hydroxy-
BDBM50426822