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Nitrofural

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Identification
Molecular formula
C12H15N5O4
CAS number
59-87-0
IUPAC name
2-(4-isopropylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide
State
State

At room temperature, nitrofural is in a solid state. It is usually encountered as a powder which makes it suitable for its intended medical applications, especially topical applications. Though it is stable at room temperature, it should be stored in a cool, dry place to maintain its efficacy.

Melting point (Celsius)
246.00
Melting point (Kelvin)
519.00
Boiling point (Celsius)
396.00
Boiling point (Kelvin)
669.00
General information
Molecular weight
315.33g/mol
Molar mass
315.3310g/mol
Density
1.6300g/cm3
Appearence

Nitrofural typically presents as a yellow crystalline solid. It has a bright coloration due to the presence of the nitro group, which is characteristic of many nitrofuran compounds. The solid is often found in a finely divided powder form for pharmaceutical applications.

Comment on solubility

Solubility Characteristics

The solubility of 2-(4-isopropylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide is a noteworthy aspect of its chemical profile. Understanding its solubility can provide insights into its behavior in different solvents and formulations.


Factors Influencing Solubility

Several factors contribute to the solubility of this compound:

  • Polarity: The presence of polar functional groups (such as amide and nitro groups) can enhance solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvents can significantly impact its solubility, particularly in water.
  • Temperature: Generally, increasing temperature can improve solubility for many compounds, though exceptions exist.

Solvent Compatibility

This compound is likely to demonstrate differing solubility profiles in various solvents:

  • Water: Due to its polar characteristics, it may exhibit moderate solubility.
  • Organic Solvents: It is expected to be more soluble in organic solvents such as ethanol and dimethyl sulfoxide (DMSO).

In summary, the solubility of 2-(4-isopropylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide is influenced by its chemical structure and interactions with various solvents. An accurate understanding of these solubility attributes is crucial for applications in pharmaceuticals and chemical synthesis.

Interesting facts

Interesting Facts about 2-(4-isopropylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide

This compound, known for its unique structure and functional groups, represents a fascinating area of research in medicinal chemistry. Here are some key points that underscore its significance:

  • Dual Pharmacophoric Nature: The presence of both a piperazine and a furan ring in its structure indicates potential biological activity, especially in targeting central nervous system disorders.
  • Versatile Synthesis: Its synthesis often employs innovative methods in organometallic chemistry, showcasing the creativity of chemists in developing complex molecules from simpler precursors.
  • Biological Implications: Compounds with similar structures have shown promise in pharmacological settings, potentially acting as anxiolytics or antidepressants. Research is ongoing to evaluate its effects on neurotransmitter systems.
  • Structure-Activity Relationship (SAR): Understanding how structural modifications affect biological activity is crucial, and this compound provides an exciting platform to explore SAR due to its complex design.

Moreover, the compound's intriguing name reflects its multifaceted nature, which can spark curiosity among chemistry students and professionals alike. As noted by chemists, "_The details in synthetic pathways often reveal underlying principles of reactivity and functionalization._" This makes studying compounds like 2-(4-isopropylpiperazin-1-yl)-N-[(5-nitro-2-furyl)methyleneamino]acetamide not just about the molecule itself, but also about the broader implications in drug development and chemical research.