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Trimethoprim Dihydrochloride

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Identification
Molecular formula
C18H24N2O4 · 2HCl
CAS number
61377-96-6
IUPAC name
2-[4-(m-tolylmethyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone;dihydrochloride
State
State

At room temperature, trimethoprim dihydrochloride is a solid compound characterized by its crystalline form.

Melting point (Celsius)
198.00
Melting point (Kelvin)
471.15
Boiling point (Celsius)
300.00
Boiling point (Kelvin)
573.15
General information
Molecular weight
290.35g/mol
Molar mass
290.3460g/mol
Density
1.1800g/cm3
Appearence

Trimethoprim dihydrochloride appears as a white to off-white crystalline powder. This compound is hygroscopic, meaning it readily absorbs moisture from the environment, and it is slightly soluble in water and lower alcohols.

Comment on solubility

Solubility of 2-[4-(m-tolylmethyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride

This compound is known for its intriguing solubility profile, which is influenced by its dihydrochloride form. Generally, compounds that are salts, like this one, tend to exhibit improved solubility in polar solvents compared to their base counterparts. Here are some key points regarding its solubility:

  • Solvent Compatibility: It is highly soluble in water due to the presence of the two hydrochloride groups, which enhances ionic interactions with water molecules.
  • Drug Formulation: The high solubility makes it particularly advantageous in pharmaceutical applications, where bioavailability is critical.
  • Temperature Dependence: Like many salts, its solubility may increase with temperature, allowing for more significant dissolution at elevated temperatures.
  • Solvent Effects: Apart from water, it may show variable solubility in organic solvents such as ethanol and methanol, depending on their polarity and hydrogen bonding capabilities.

In summary, the solubility of 2-[4-(m-tolylmethyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride underscores its potential in various chemical and pharmaceutical applications, characterized by its notable behavior in aqueous environments.

Interesting facts

Interesting Facts about 2-[4-(m-tolylmethyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride

This compound is a fascinating example of a piperazine derivative, which showcases the intricate relationship between structure and biological activity. Here are some noteworthy aspects:

  • Complex Structure: The presence of both piperazine and a trimethoxyphenyl group in its structure points to its potential in medicinal chemistry, as these components often contribute to improved pharmacological properties.
  • Biological Relevance: Due to the piperazine ring, this compound might mimic neurotransmitters, highlighting its potential as a candidate for drug development targeting diseases related to the central nervous system.
  • Diverse Applications: Compounds like this one are often explored for their use in various therapeutic areas, including anti-depressants and anti-anxiety medications.
  • Mechanism of Action: With its unique design, researchers may study its mechanism in enzyme inhibition or receptor binding, providing insights that could lead to innovative treatments.

As you delve into studies involving this compound, keep in mind the implications of substituent variations, as even slight modifications can lead to significantly different biological activities. It's an exciting time for medicinal chemists, and compounds like 2-[4-(m-tolylmethyl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride are at the forefront of developing new therapeutic agents.

Synonyms
Acetophenone, 2-(4-(m-methylbenzyl)piperazinyl)-3',4',5'-trimethoxy-, dihydrochloride
17755-60-1
DTXSID20170330
1-(m-Methylbenzyl)-4-(3,4,5-trimethoxybenzoylmethyl)piperazine dihydrochloride
2-(4-(m-Methylbenzyl)piperazinyl)-3',4',5'-trimethoxyacetophenone dihydrochloride
Piperazine, 1-(m-methylbenzyl)-4-(3,4,5-trimethyoxybenzoylmethyl)-, dihydrochloride
DTXCID0092821