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Loperamide Hydrochloride

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Identification
Molecular formula
C29H34ClN3O4
CAS number
34552-83-5
IUPAC name
2-(4-methoxyphenoxy)-N-(2-methoxyphenyl)-N-(2-pyrrolidin-1-ium-1-ylethyl)acetamide;chloride
State
State
At room temperature, Loperamide Hydrochloride is typically a solid, existing as a crystalline powder.
Melting point (Celsius)
222.00
Melting point (Kelvin)
495.00
Boiling point (Celsius)
410.20
Boiling point (Kelvin)
683.20
General information
Molecular weight
513.51g/mol
Molar mass
513.5110g/mol
Density
1.1900g/cm3
Appearence

The compound Loperamide Hydrochloride is typically found as a white to off-white crystalline powder. The compound is highly soluble in water, contributing to its effectiveness in its intended application.

Comment on solubility

Solubility Insights for 2-(4-methoxyphenoxy)-N-(2-methoxyphenyl)-N-(2-pyrrolidin-1-ium-1-ylethyl)acetamide;chloride

The solubility of the compound 2-(4-methoxyphenoxy)-N-(2-methoxyphenyl)-N-(2-pyrrolidin-1-ium-1-ylethyl)acetamide;chloride can be influenced by various factors, including its molecular structure and the presence of polar groups. Here are some key points regarding its solubility:

  • Polarity: The presence of multiple methoxy groups and a pyrrolidinium ion suggests a level of polarity, potentially leading to improved solubility in polar solvents such as water.
  • Ionization: The quaternary ammonium nature of the pyrrolidinium moiety may enhance its solubility in ionic solvents due to ionic interactions.
  • Hydrogen Bonding: The ability to form hydrogen bonds with water molecules can also play a crucial role in solubility. The amide functional group is known for its hydrogen bonding capabilities.

In conclusion, it is reasonable to anticipate that 2-(4-methoxyphenoxy)-N-(2-methoxyphenyl)-N-(2-pyrrolidin-1-ium-1-ylethyl)acetamide;chloride would display good solubility in polar solvents, especially given its structural features that promote interactions with solvent molecules. As always, experimental data is essential to affirm these theoretical expectations.

Interesting facts

Exploring 2-(4-methoxyphenoxy)-N-(2-methoxyphenyl)-N-(2-pyrrolidin-1-ium-1-ylethyl)acetamide;chloride

This fascinating compound is notable for its complex structure and potential applications in medicinal chemistry. Here are some compelling facts about this compound:

  • Pharmacological Potential: The unique arrangement of functional groups in this compound suggests it may exhibit interesting biological activity, potentially making it a candidate for pharmaceutical development.
  • Ionization: The presence of the pyrrolidinium ion indicates that this compound could possess enhanced solubility in biological systems, enhancing its utility in drug formulations.
  • Structural Diversity: The inclusion of methoxy groups can influence the electronic properties and steric effects, which may ultimately affect the compound's interaction with biological targets.

Researchers are drawn to this compound due to its structural complexity and the implications it holds for developing new therapies. Studies on its synthesis and reactivity may provide insights into novel pathways for drug design. As one researcher potentially quipped, “The more complex the molecule, the more intriguing the possibilities.”

Continued investigation into compounds like this one is essential for pushing the boundaries of medicinal chemistry and discovering innovative solutions to challenging health issues.

Synonyms
27471-59-6
N-(2-Methoxyphenyl)-N-(2-pyrrolidinoethyl)-4-methoxyphenoxyacetamide hydrochloride
2-(p-Methoxyphenoxy)-N-(2-(1-pyrrolidinyl)ethyl)-o-acetanisidide hydrochloride
o-Acetanisidide, 2-(p-methoxyphenoxy)-N-(2-(1-pyrrolidinyl)ethyl)-, monohydrochloride
RefChem:366321