p-Methoxyphenylacetic acid | Solubility of Things

Identification

Molecular formula

C₉H₁₀O₃

CAS number

104-01-8

IUPAC name

2-(4-methoxyphenyl)acetic acid

State

At room temperature, p-Methoxyphenylacetic acid is typically in a solid state. It can exist as a crystalline powder, which is a typical physical state for many aromatic carboxylic acids.

Melting point (Celsius)

94.50

Melting point (Kelvin)

367.70

Boiling point (Celsius)

336.60

Boiling point (Kelvin)

609.80

General information

Molecular weight

166.18g/mol

Molar mass

166.1750g/mol

Density

1.1614g/cm³

Appearence

2-(4-Methoxyphenyl)acetic acid, commonly known as p-Methoxyphenylacetic acid, appears as a white to off-white crystalline solid. The compound is often finely powdered and has a faint aromatic scent typical of methoxy and phenyl derivatives.

Comment on solubility

Solubility of 2-(4-Methoxyphenyl)acetic Acid

2-(4-Methoxyphenyl)acetic acid, with its unique structure, exhibits a range of solubility behaviors that are noteworthy. This compound is characterized by its moderate solubility in various solvents, which can be influenced by several factors:

Polarity: Due to the presence of the methoxy group (-OCH₃), the compound shows some polar characteristics, enhancing its solubility in polar solvents like water.
Solvent Compatibility: It is readily soluble in organic solvents such as ethanol and methanol, which are known to dissolve polar organic compounds effectively.
Temperature Effects: The solubility can increase with temperature, making it easier to dissolve in heated solvents.
pH Dependency: The acidic nature of the carboxylic acid group can affect solubility in different pH environments, potentially increasing solubility in basic conditions where it becomes ionized.

In summary, the solubility of 2-(4-methoxyphenyl)acetic acid varies significantly depending on the solvent and environmental conditions. As a general guideline, it is best to consider both polar and non-polar solvents for effective dissolution, keeping in mind the effect of temperature and pH on its solubility profile.

Interesting facts

Interesting Facts About 2-(4-Methoxyphenyl)acetic Acid

2-(4-Methoxyphenyl)acetic acid, often referred to in scientific literature for its unique properties, has garnered interest in various fields of chemistry and pharmacology. Below are some engaging facts about this compound:

Pharmaceutical Relevance: This compound is noted for its role as a precursor in the synthesis of non-steroidal anti-inflammatory drugs (NSAIDs). Its structural characteristics lend it the ability to inhibit certain enzymes, making it a valuable entity in drug design.
Structural Features: The presence of a methoxy group (-OCH₃) on the phenyl ring enhances the lipophilicity of the molecule, which can influence its biological activity. The acetic acid functional group plays a crucial role in reactivity and solubility.
Potential Therapeutic Applications: There is ongoing research exploring the anti-inflammatory and analgesic properties of various derivatives of 2-(4-methoxyphenyl)acetic acid. The modifications to its structure can lead to compounds with varying efficacy and side effects, making it a compelling object of study.
Synthesis Pathways: The synthetic routes to obtain 2-(4-methoxyphenyl)acetic acid are diverse, enabling chemists to modify reaction conditions to obtain high yields. This versatility makes it appealing for research and industrial applications.
Safety and Handling: Like many organic acids, proper safety measures are essential when handling this compound. Researchers are advised to wear appropriate protective gear, such as gloves and safety goggles, to ensure safe manipulation in the lab.

In conclusion, 2-(4-Methoxyphenyl)acetic acid stands as a prime example of how a single compound can influence multiple facets of science, from medicinal chemistry to synthetic methodologies. Its unique structural elements and potential applications make it an exciting subject for ongoing research.

Synonyms

4-Methoxyphenylacetic acid

104-01-8

2-(4-methoxyphenyl)acetic acid

Homoanisic acid

p-Methoxyphenylacetic acid

Benzeneacetic acid, 4-methoxy-

(4-Methoxyphenyl)acetic acid

4-Methoxybenzeneacetic acid

2-(p-Anisyl)acetic acid

(p-Methoxyphenyl)acetic acid

p-Anisylacetic acid

p-Methoxy-alpha-toluic acid

MFCD00004345

NSC 27799

Homoanisate

4-Methoxyphenylaceticacid

CHEBI:55501

Acetic acid, (p-methoxyphenyl)-

EINECS 203-166-4

AJP2V8U5K6

Homo-p-anisic acid

Acetic acid, p-methoxyphenyl-

p-Methoxy-a-toluate

BRN 1101737

(4-Methoxy-phenyl)-acetic acid

2-(p-Anisyl)acetate

4-Methoxybenzeneacetate

p-methoxyphenyl-acetate

p-Methoxy-alpha-toluate

4-methoxy-benzeneacetate

4-methoxyphenacetic acid

p-Methoxy-a-toluic acid

(p-Methoxyphenyl)acetate

NSC-27799

NSC-65597

p-methoxyphenyl-acetic acid

UNII-AJP2V8U5K6

4-Methoxy phenylacetic acid

4-methoxyphenylacetate

(4-Methoxy-phenyl)-acetate

4-methoxy-benzeneacetic acid

p-Methoxy-.alpha.-toluic acid

DTXSID1059288

4-10-00-00544 (Beilstein Handbook Reference)

2-(P-METHOXYPHENYL)ACETIC ACID

WLN: QV1R DO1

4-Methoxyphenyl acetic acid

p-Methoxyphenylacetate

ONONETIN_met012

p-Methoxy-I+--toluate

(4-methoxyphenyl)acetate

Epitope ID:119696

p-methoxyphenyl acetic acid

p-Methoxy-I+--toluic acid

para-methoxyphenylacetic acid

NCIOpen2_000187

p-methoxy phenyl acetic acid

SCHEMBL240822

(4-methoxyphenyl)-acetic acid

(4methoxy-phenyl)-acetic acid

(4-methoxyphenyl)ethanoic acid

CHEMBL1760597

DTXCID3032836

2-(4-methoxyphenyl)-acetic acid

[4-(methyloxy)phenyl]acetic acid

BDBM231634

BCP27492

NSC27799

NSC65597

STR06306

acetic acid, 2-(4-methoxyphenyl)-

BBL009361

s6273

STK498739

AKOS000119748

AC-2432

CS-W004206

FM71195

HY-W004206

PS-3381

PD124018

SY001095

M0742

NS00023274

EN300-19915

D70488

M13960

4-Methoxyphenylacetic acid, ReagentPlus(R), 99%

AE-562/40223956

Q63398108

F3308-1732

Z104476074

4-Methoxyphenylacetic acid, Vetec(TM) reagent grade, 98%

203-166-4