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Sibutramine

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Identification
Molecular formula
C17H26NO1
CAS number
106650-56-0
IUPAC name
2-[(4-methoxyphenyl)methylamino]-1-phenyl-propan-1-ol
State
State

At room temperature, sibutramine is a solid. It is typically handled in powder form and is known for being chemically stable under standard atmospheric conditions.

Melting point (Celsius)
193.00
Melting point (Kelvin)
466.15
Boiling point (Celsius)
479.70
Boiling point (Kelvin)
752.85
General information
Molecular weight
279.39g/mol
Molar mass
279.3870g/mol
Density
1.2086g/cm3
Appearence

Sibutramine typically presents as a white to off-white crystalline powder. It is usually supplied and handled in this solid state for pharmaceutical use. Its appearance may vary slightly depending on the specific formulation and any additional inert ingredients it may be mixed with in medicinal preparations.

Comment on solubility

Solubility of 2-[(4-methoxyphenyl)methylamino]-1-phenyl-propan-1-ol

The solubility of 2-[(4-methoxyphenyl)methylamino]-1-phenyl-propan-1-ol can be considered quite interesting due to its unique chemical structure. Solubility in solvents is influenced by a variety of factors, and this compound exhibits a distinctive profile:

  • Polarity: The presence of the hydroxyl group (-OH) enhances hydrogen bonding, which generally increases solubility in polar solvents like water.
  • Non-polar Character: The aromatic methoxy group and the phenyl rings contribute hydrophobic characteristics that may limit solubility in highly polar solvents.
  • Solvent Interactions: This compound may show substantial solubility in various organic solvents such as ethanol, methanol, or dimethyl sulfoxide (DMSO) due to compatible polar and non-polar interactions.

As a point of reference, it is often noted in chemical assessments that "like dissolves like." Therefore, understanding the balance of polar and non-polar aspects in 2-[(4-methoxyphenyl)methylamino]-1-phenyl-propan-1-ol is crucial for predicting its solubility behavior.

In summary, the solubility characteristics of this compound are a fine example of how molecular structure influences solubility; it benefits from both hydrophilic and hydrophobic interactions, making it potentially soluble in a range of solvents while also exhibiting limitations in highly polar environments.

Interesting facts

Interesting Facts about 2-[(4-methoxyphenyl)methylamino]-1-phenyl-propan-1-ol

This compound, also known as a selective serotonin reuptake inhibitor (SSRI), is an intriguing subject in pharmacology and medicinal chemistry. SSRIs are widely utilized in the treatment of various mood disorders, including depression and anxiety. Here are some captivating aspects of this particular compound:

  • Mechanism of Action: The compound works by inhibiting the reuptake of serotonin in the brain, thereby increasing its availability in the synaptic cleft. This is crucial for enhancing mood and emotional stability.
  • Chemical Structure: It features multiple functional groups, such as a methoxy group and an amino group, which contribute to its biological activity and solubility. The presence of the phenyl groups enhances its interaction with biological receptors.
  • Research Focus: Researchers are continuously exploring derivatives of this compound to improve efficacy, reduce side effects, and extend its therapeutic applications.
  • Side Effects: Like many SSRIs, users may experience side effects, which can include nausea, insomnia, or changes in weight. Understanding these effects helps mitigate risks during treatment.

In the vast realm of organic chemistry, compounds like 2-[(4-methoxyphenyl)methylamino]-1-phenyl-propan-1-ol exemplify how structural nuances can lead to significant pharmacological effects. As we continue to unravel the complexities of such compounds, we can expect innovative developments in the field of mental health therapy.

“The study of chemistry involves not only the understanding of atoms and molecules but also the exploration of their endless possibilities.”

Synonyms
SCHEMBL5265860