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Identification
Molecular formula
C17H17NO5S
CAS number
162558-25-8
IUPAC name
2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carbohydroxamic acid
State
State

At room temperature, this compound is found in a solid state, typically as a powder.

Melting point (Celsius)
238.50
Melting point (Kelvin)
511.70
Boiling point (Celsius)
523.50
Boiling point (Kelvin)
796.70
General information
Molecular weight
346.38g/mol
Molar mass
346.3830g/mol
Density
1.3700g/cm3
Appearence

This compound typically appears as an off-white to pale yellow powder. It may be crystalline in nature depending on the purity and specific conditions under which it is synthesized and stored.

Comment on solubility

Solubility of 2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carbohydroxamic acid

The solubility of the compound 2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carbohydroxamic acid (C17H17NO5S) can be influenced by several factors. As a sulfonamide derivative, it may exhibit notable solubility characteristics based on its polar and nonpolar functional groups. Here are some key points to consider:

  • Polarity: The presence of hydroxamic acid and sulfonyl groups contributes to the overall polarity of the molecule, which can enhance its solubility in polar solvents like water.
  • Solvent Effects: It is likely to be more soluble in organic solvents such as methanol, ethanol, or dimethyl sulfoxide (DMSO) than in nonpolar solvents due to its structural composition.
  • Hydrogen Bonding: The ability of the hydroxamic acid moiety to form hydrogen bonds can facilitate solubility through interactions with solvent molecules.
  • Temperature Sensitivity: Increased temperature may improve solubility, particularly in solvent systems where the molecule exhibits limited solubility at room temperature.

In summary, while the solubility of this compound is likely favorable in polar solvents due to its functional groups, the exact solubility would need to be empirically determined under various conditions. As always, when assessing solubility, consider both environmental conditions and solvent selection as key factors for successful dissolution.

Interesting facts

Interesting Facts about 2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carbohydroxamic acid

This complex compound, often studied for its unique structural features, represents a fascinating intersection of various functional groups. Its design leverages the isoquinoline framework, which is known for its presence in many natural product alkaloids, thus providing a rich backdrop for medicinal chemistry.

Here are some compelling points about this compound:

  • Versatile Applications: Compounds like this one are often explored for their potential as pharmaceuticals. They may exhibit activity against a variety of diseases, particularly in cancer research and the development of new antibiotics.
  • Structural Diversity: The presence of the sulfonyl group and the methoxyphenyl moiety enhances the compound's binding interactions with biological targets, making it an interesting subject for drug discovery.
  • Hydroxamic Acid Derivatives: The hydroxamic acid part of the molecule is crucial in biochemistry; it acts as an important ligand for metal ions, which can influence enzyme activity and assist in various biochemical pathways.
  • Research Interest: Studies have indicated the potential for these compounds to function as protease inhibitors. Proteases are enzymes that play critical roles in various biological processes, and inhibiting them can lead to the development of therapeutic agents.

Moreover, the integration of **methoxy** and **sulfonyl groups** introduces unique electronic effects, which can significantly alter the reactivity of the compound. As such, understanding and synthesizing this kind of compound not only advances the field of synthetic chemistry but also provides valuable insights into new avenues for drug design and development.

"Exploring novel chemical compounds is like discovering new worlds; each structure tells a story of potential mysteries waiting to be unlocked."

Synonyms
N-hydroxy-2-(4-methoxyphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline-3-carboxamide
236403-25-1
2-(4-Methoxyphenylsulfonyl)-1,2,3,4-tetrahydroisoquinoline-3-carbohydroxamic acid