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Gefitinib

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Identification
Molecular formula
C22H24ClFN4O3
CAS number
184475-35-2
IUPAC name
2-(4-methylpiperazin-1-yl)imino-1-(4-phenoxyphenyl)ethanone
State
State

At room temperature, gefitinib is typically in a solid state, existing as a crystalline powder.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
510.00
Boiling point (Kelvin)
783.15
General information
Molecular weight
446.91g/mol
Molar mass
446.9070g/mol
Density
1.3578g/cm3
Appearence

Gefitinib typically appears as a white to slightly yellowish crystalline powder. Its appearance is consistent with many other active pharmaceutical ingredients derived from complex organic synthesis.

Comment on solubility

Solubility of 2-(4-methylpiperazin-1-yl)imino-1-(4-phenoxyphenyl)ethanone

The solubility of 2-(4-methylpiperazin-1-yl)imino-1-(4-phenoxyphenyl)ethanone can be influenced by various factors which are crucial for its application in different chemical environments.

Factors Affecting Solubility

  • Polarity: The presence of polar functional groups can enhance solubility in polar solvents.
  • Molecular Size: Larger molecules often exhibit reduced solubility due to steric hindrance.
  • Hydrogen Bonding: The ability to form hydrogen bonds improves solubility in water and other proton donor solvents.

While specific solubility data for this compound might be limited, a few observations can be made:

  • Given its structural components, it may show moderate solubility in organic solvents like ethanol and dimethyl sulfoxide (DMSO).
  • Its solubility in water may be less favorable due to the bulky phenoxy and piperazine groups.

It is important to note that solubility is crucial for applications in pharmaceuticals and chemical synthesis, where it can dictate the bioavailability and reactivity of the compound.

Summary

Understanding the solubility characteristics of 2-(4-methylpiperazin-1-yl)imino-1-(4-phenoxyphenyl)ethanone is essential for optimizing its use in various chemical formulations and processes. Further investigation through empirical tests would be beneficial to establish precise solubility parameters.

Interesting facts

Interesting Facts about 2-(4-methylpiperazin-1-yl)imino-1-(4-phenoxyphenyl)ethanone

This compound is a fascinating member of the class of organic compounds that combines unique structural features with potential applications. Here are some engaging insights:

  • Dual Functionality: The compound contains both a piperazine ring and a phenyl moiety, which can contribute to its bioactivity. Compounds with piperazine functional groups are often known for their pharmacological properties.
  • Research Applications: Due to its structural composition, this compound might exhibit important properties such as antidepressant, antipsychotic, or anticancer activities, making it a candidate for medicinal chemistry research.
  • Reactivity: The imino group in the structure can participate in various chemical reactions, potentially leading to the synthesis of other complex molecules, which is of great interest in synthetic organic chemistry.
  • Structure-Activity Relationship (SAR): This compound can be studied for the relationship between its chemical structure and biological activity, helping scientists to design more effective pharmaceuticals with optimized properties.
  • Combating Drug Resistance: In the quest for innovative treatments, compounds like this provide a platform for developing medications that can overcome drug resistance in various diseases, particularly in cancer therapy.

In summary, 2-(4-methylpiperazin-1-yl)imino-1-(4-phenoxyphenyl)ethanone exemplifies how intricate chemical structures can lead to significant pharmacological exploration and innovation in therapeutic areas. Its potential benefits reflect just how crucial the study of compounds like this is to advancing medical science.