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Olanzapine

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Identification
Molecular formula
C17H20N4O
CAS number
132539-06-1
IUPAC name
2-(4-methylpiperazin-1-yl)imino-1-(4-phenylphenyl)ethanone
State
State

Olanzapine is a solid at room temperature, generally supplied in the form of tablets for pharmaceutical use. It is used primarily in medications for the treatment of various psychological disorders.

Melting point (Celsius)
195.00
Melting point (Kelvin)
468.15
Boiling point (Celsius)
368.90
Boiling point (Kelvin)
642.05
General information
Molecular weight
312.44g/mol
Molar mass
312.4390g/mol
Density
1.2320g/cm3
Appearence

Olanzapine appears as a white to off-white crystalline powder. It is practically insoluble in water but soluble in methanol, acetone, and a 0.1N hydrochloric acid solution. The compound exhibits polymorphism, with different crystalline forms having distinct properties.

Comment on solubility

Solubility of 2-(4-methylpiperazin-1-yl)imino-1-(4-phenylphenyl)ethanone

The solubility of 2-(4-methylpiperazin-1-yl)imino-1-(4-phenylphenyl)ethanone can be understood through several key factors:

  • Polarity: The overall polarity of the compound plays a significant role in its solubility in various solvents. Generally, polar solvents will dissolve polar compounds effectively.
  • Functional Groups: The presence of the piperazine ring and phenyl groups can influence its interaction with solvents. These groups may enhance solubility in some organic solvents while possibly reducing solubility in aqueous environments.
  • Hydrogen Bonding: The capability of the compound to form hydrogen bonds can also affect its solubility. Compounds that can engage in hydrogen bonding tend to have improved solubility in polar solvents.

In practice, one might observe the following solubility characteristics:

  1. It may demonstrate reasonable solubility in dimethyl sulfoxide (DMSO) or methanol due to the capability of these solvents to interact with the molecule's polar regions.
  2. Conversely, it could exhibit limited solubility in water, attributed to the hydrophobic nature of the phenyl rings.

To optimize your experiments, it is advisable to test solubility in various solvents, considering both similarity and polarity of the solvent and solute. As the saying goes, "like dissolves like," which remains a fundamental principle in understanding molecular interactions and solubility.

Interesting facts

Interesting Facts about 2-(4-methylpiperazin-1-yl)imino-1-(4-phenylphenyl)ethanone

This intriguing compound is a member of the vast class of organic molecules known for their potential in pharmaceuticals and material science. Here are some engaging facts about this compound:

  • Structure and Functionality: The compound features an imine functional group, which is quite significant. Imines are known to participate in various chemical reactions, making this compound a versatile entity in synthetic organic chemistry.
  • Piperazine Influence: The presence of the piperazine moiety (4-methylpiperazine) is noteworthy. Piperazine derivatives are common in drug development due to their biological activity and ability to act as ligands for neurotransmitter receptors. This compound may exhibit interesting interactions in biological systems.
  • Potential Applications: Given its unique structure, this compound could be explored for its medicinal properties, potentially leading to new treatments or therapeutic agents in fields such as psychiatry or neurology.
  • Diversity of Phenyl Groups: The incorporation of phenyl groups adds significant stability and can enhance the compound's interactions with biological targets, possibly leading to increased efficacy in medicinal chemistry.
  • Research Relevance: Researchers are increasingly interested in compounds with complex structures and multipodal functionalities, like this one, as they offer varied pathways for exploration in drug design and materials science.

As a specialized compound with a complex architecture, 2-(4-methylpiperazin-1-yl)imino-1-(4-phenylphenyl)ethanone serves as a prime example of the intricate relationship between chemical structure and biological function. Its potential applications and significance in drug development make it a compound worthy of further investigation.