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2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine

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Identification
Molecular formula
C14H12N2O2S
CAS number
209385-16-0
IUPAC name
2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
State
State

At room temperature, this compound is in a solid state. Its crystalline form provides it with a rigid structure, typical for many pharmaceutical compounds of this kind.

Melting point (Celsius)
168.50
Melting point (Kelvin)
441.70
Boiling point (Celsius)
460.80
Boiling point (Kelvin)
734.00
General information
Molecular weight
270.32g/mol
Molar mass
270.3180g/mol
Density
1.3600g/cm3
Appearence

This compound typically appears as a crystalline solid. Crystalline forms can vary but generally, it presents a structured, well-defined shape showcasing facets and sometimes a powdery form when crushed.

Comment on solubility

Solubility of 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine

The solubility properties of 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine can be quite interesting, particularly due to its unique chemical structure that features both imidazo and pyridine functionalities.

Factors Influencing Solubility:

  • Polarity: The presence of the sulfonyl group can enhance solubility in polar solvents.
  • Hydrogen Bonding: The nitrogen atoms in the imidazo and pyridine rings may participate in hydrogen bonding, affecting solubility in various solvents.
  • pH Dependency: The solubility may vary significantly with pH, as protonation and deprotonation can influence the overall charge and polarity.

While solubility data specific to this compound may be limited, similar compounds generally show the following trends:

  • Better solubility in polar organic solvents such as methanol and ethanol.
  • Limited solubility in nonpolar solvents such as hexane.

Given its structural characteristics, it can often be predicted that 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine will exhibit reasonable solubility in a variety of organic solvents, making it a versatile compound in chemical applications.

Interesting facts

Interesting Facts about 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine

2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine is a fascinating compound that found its significance particularly in the fields of pharmaceuticals and organic chemistry. Here are some intriguing details:

  • Pharmaceutical Potential: This compound is studied for its potential as a drug candidate, particularly in targeting various biological mechanisms due to its unique structure. Researchers are investigating its effects on cellular pathways and possible applications in cancer therapy.
  • Structural Features: The imidazo[1,2-a]pyridine moiety presents interesting electronic properties due to the presence of both nitrogen heteroatoms and the aromatic system. This leads to enhanced reactivity and selectivity in various organic reactions.
  • Versatile Synthesis: There are multiple synthetic routes available to create this compound, often involving the use of catalysts or specific reaction conditions that can optimize yield. This versatility makes it a favorite among synthetic chemists.
  • Mechanism of Action: Although research is ongoing, preliminary studies suggest that compounds like 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine may interfere with specific kinases in signaling pathways, potentially leading to breakthroughs in treating resistant forms of cancer.
  • Multifunctionality: Beyond medicinal applications, this compound's unique structure allows it to be explored for uses in material science, particularly in the development of organic semiconductors due to its electronic properties.

In summary, 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine is not just another chemical entity; it embodies the intersection of innovation and scientific inquiry, making it a critical subject of study for both aspiring chemists and seasoned researchers alike. Keep an eye on this compound—it may play a pivotal role in future advancements!

Synonyms
Zolimidine
1222-57-7
Solimidin
Zolimidin
Zolimidine [INN]
Zolimidina
solimidine
Zolimidina [DCIT]
Zolimidinum
ZOLIRIDINE
Zolimidinum [INN-Latin]
UNII-YCF001N8QB
EINECS 214-947-4
YCF001N8QB
Zolimidine (INN)
BRN 0752451
DTXSID9057630
ZOLIMIDINE [MI]
ZOLIMIDINE [MART.]
ZOLIMIDINE [WHO-DD]
2-(4-(Methylsulfonyl)phenyl)imidazo(1,2-a)pyridine
Imidazo(1,2-a)pyridine, 2-(4-(methylsulfonyl)phenyl)-
DTXCID6031419
5-23-12-00328 (Beilstein Handbook Reference)
2-(4-methanesulfonylphenyl)imidazo[1,2-a]pyridine
Imidazo(1,2-a)pyridine, 2-(p-(methylsulfonyl)phenyl)-
Zolimidinum (INN-Latin)
ZOLIMIDINE (MART.)
2-(4-methanesulfonylphenyl)imidazo(1,2-a)pyridine
2-[4-(methylsulfonyl)phenyl]imidazo[1,2-a]pyridine
2-(4-(Methylsulfonyl)phenyl)imidazo[1,2-a]pyridine
Solmidin
Imidazo(1,2-a)pyridine, 2-(4-(methylsulfonyl)phenyl)-(9CI)
214-947-4
vsliuwlpfrvcdl-uhfffaoysa-n
2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
Solimidin; Zolimidin
SCHEMBL932657
2-(p-(Methylsulfonyl)phenyl)imidazol(1,2-a)pyridine
CHEMBL2105534
CHEBI:135125
GLXC-21152
Tox21_113899
AKOS017271280
AT26590
DB13593
NCGC00261979-01
CAS-1222-57-7
HY-108278
CS-0028131
NS00023981
D07075
EN300-6492993
Q8073565
BRD-K45125084-001-01-4
Z82177056