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N-(4-Nitrophenyl)glycine

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Identification
Molecular formula
C8H8N2O4
CAS number
16297-54-0
IUPAC name
2-(4-nitroanilino)-2-oxo-acetic acid
State
State

At room temperature, this compound exists in a solid state, and it is typically handled as a powdery substance.

Melting point (Celsius)
238.00
Melting point (Kelvin)
511.15
Boiling point (Celsius)
378.00
Boiling point (Kelvin)
651.15
General information
Molecular weight
196.16g/mol
Molar mass
196.1480g/mol
Density
1.5042g/cm3
Appearence

N-(4-Nitrophenyl)glycine appears as a yellow crystalline powder. This compound is characterized by its vibrant coloration due to the presence of the nitro group.

Comment on solubility

Solubility of 2-(4-nitroanilino)-2-oxo-acetic acid

The solubility of 2-(4-nitroanilino)-2-oxo-acetic acid is influenced by various factors including temperature, pH, and the presence of solvents. Understanding its solubility characteristics is crucial for applications in chemical synthesis and medicinal chemistry.

Factors Affecting Solubility

  • Polarity: This compound possesses polar functional groups, which may lead to enhanced solubility in polar solvents such as water.
  • pH Variability: The acidic nature of the carboxylic acid group can lead to varying solubility across different pH levels, often increasing in more basic environments.
  • Temperature: Increasing temperature generally increases solubility for many organic compounds, and this may also apply to this particular acid.

Solubility Observations

Typically, compounds like 2-(4-nitroanilino)-2-oxo-acetic acid demonstrate the following solubility behavior:

  • Moderately soluble: Often dissolving in organic solvents or alcohols.
  • Aqueous solutions: May show limited solubility in pure water but can be more soluble in buffered solutions.

In summary, while the specific solubility of 2-(4-nitroanilino)-2-oxo-acetic acid can vary widely based on the conditions outlined above, its unique structural features suggest a capacity for reasonable solubility in appropriate solvents. Understanding these nuances can aid in optimizing its usage in various chemical applications.

Interesting facts

Interesting Facts about 2-(4-nitroanilino)-2-oxo-acetic acid

2-(4-nitroanilino)-2-oxo-acetic acid is a fascinating compound due to its unique structure and properties. Here are some key points that highlight its significance in the field of chemistry:

  • Applications in Pharmaceuticals: This compound is often used as an intermediate in the synthesis of various pharmaceutical agents. Its ability to interact with biological systems makes it a subject of interest in drug development.
  • Functional Groups: The presence of both a nitro group and a carboxylic acid group in its structure endows it with interesting reactivity and potential for forming hydrogen bonds. This can influence its solubility and interaction with other biomolecules.
  • Research Significance: Studies have shown that compounds like 2-(4-nitroanilino)-2-oxo-acetic acid can be useful in investigating the mechanisms of certain biological pathways, particularly in the development of anticancer drugs.
  • Analytical Techniques: Its unique characteristics allow it to be analyzed using various techniques such as NMR spectroscopy, mass spectrometry, and IR spectroscopy, which help in understanding its structure and reactivity.
  • Cross-Disciplinary Interests: This compound serves as a vital link between organic chemistry and medicinal chemistry, demonstrating the importance of interdisciplinary approaches in advancing scientific knowledge.

In summary, 2-(4-nitroanilino)-2-oxo-acetic acid is not just another compound; it is a gateway into the realms of medicinal chemistry and synthetic organic chemistry. Its role as a versatile reactant underscores the collaborative nature of modern chemical research.

Synonyms
4-Nitrophenyloxamic acid
103-94-6
2-((4-Nitrophenyl)amino)-2-oxoacetic acid
Oxalyl-p-nitroaniline
2-(4-nitroanilino)-2-oxoacetic acid
4'-Nitrooxanilic acid
N-(4-Nitrophenyl)oxamic acid
OXANILIC ACID, 4'-NITRO-
((4-Nitrophenyl)amino)oxoacetic acid
Kyselina N-(4-nitrofenyl)oxamova
D7SP5WLZ3P
EINECS 203-160-1
NSC 57783
BRN 2809447
Acetic acid, ((4-nitrophenyl)amino)oxo-
Acetic acid, [(4-nitrophenyl)amino]oxo-
Kyselina N-(4-nitrofenyl)oxamova [Czech]
P-nitrophenyloxamic acid
NSC-57783
[(4-nitrophenyl)carbamoyl]formic acid
Acetic acid, 2-((4-nitrophenyl)amino)-2-oxo-
2-12-00-00392 (Beilstein Handbook Reference)
[(4-nitrophenyl)amino]oxoacetic acid
2-[(4-Nitrophenyl)amino]-2-oxoacetic acid
Acetic acid, 2-[(4-nitrophenyl)amino]-2-oxo-
MFCD00014709
UNII-D7SP5WLZ3P
Acetic acid,2-[(4-nitrophenyl)amino]-2-oxo-
N-(4-nitrophenyl)-oxamic acid
SCHEMBL3189929
DTXSID6059285
(4-nitroanilino)(oxo)acetic acid
ZEJKSYPGUAUQKW-UHFFFAOYSA-N
NSC57783
AKOS009158372
AS-65253
2-((4-Nitrophenyl)amino)-2-oxoaceticacid
DB-040496
CS-0321507
NS00023268
H27795
203-160-1