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Losartan

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Identification
Molecular formula
C22H22ClKN6O
CAS number
114798-26-4
IUPAC name
2-[4-phenyl-2-(sulfanylmethyl)butanoyl]imino-2-[5-(tetrazol-1-ylmethyl)-2-thienyl]acetic acid
State
State

Losartan is typically in a solid state at room temperature.

Melting point (Celsius)
183.00
Melting point (Kelvin)
456.15
Boiling point (Celsius)
362.00
Boiling point (Kelvin)
635.15
General information
Molecular weight
422.44g/mol
Molar mass
422.4430g/mol
Density
1.4800g/cm3
Appearence

Losartan is a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[4-phenyl-2-(sulfanylmethyl)butanoyl]imino-2-[5-(tetrazol-1-ylmethyl)-2-thienyl]acetic acid

The solubility of the compound with the chemical formula C22H22ClKN6O is influenced by various factors due to its complex structure. Understanding its solubility characteristics is essential for applications in pharmaceuticals and material science.

Factors Affecting Solubility

This compound is composed of several functional groups that can significantly affect its solubility:

  • Presence of polar groups: The –Cl and –N6 moieties suggest potential for hydrogen bonding with solvents, likely enhancing solubility in polar solvents.
  • Hydrophobic regions: The presence of phenyl and thienyl groups indicates parts of the molecule may be hydrophobic, leading to decreased solubility in water but intriguingly soluble in organic solvents like ethanol or DMSO.
  • Size and structure: The molecular size and intricate configuration could complicate solubility, potentially leading to lower miscibility in water.

General Solubility Insight

In general, the solubility of such compounds can often be summarized as:

  • Good solubility in polar organic solvents (e.g., methanol, DMSO)
  • Moderate to low solubility in water, which can be crucial for biological systems

Therefore, while the complex nature of 2-[4-phenyl-2-(sulfanylmethyl)butanoyl]imino-2-[5-(tetrazol-1-ylmethyl)-2-thienyl]acetic acid suggests potential for interaction with various solvents, the actual solubility will vary and should be evaluated on a case-by-case basis.

Interesting facts

2-[4-Phenyl-2-(sulfanylmethyl)butanoyl]imino-2-[5-(tetrazol-1-ylmethyl)-2-thienyl]acetic acid

This compound is a complex organic molecule that presents a captivating interplay of functional groups and pharmacological potential. Here's a closer look at what makes this compound particularly interesting:

Structural Highlights

  • Phenyl Group: The presence of a phenyl group often contributes to the molecule's chemical stability and may influence its biological properties.
  • Sulfanylmethyl Function: The sulfanylmethyl moiety adds a unique layer of complexity that can enhance reactivity and properties.
  • Tetrazole Ring: Known for its ability to form strong hydrogen bonds, the tetrazole ring is also a favorable scaffold in medicinal chemistry.

Potential Applications

This compound may prove beneficial in various fields, primarily in pharmaceuticals. Here are some potential applications:

  • It could serve as a scaffold for developing new anti-inflammatory or antimicrobial agents.
  • Given the tetrazole group, there may be implications in creating antihypertensive drugs.
  • The unique combination of the thienyl and acetic acid functionalities could lead to innovative approaches in cancer therapy.

Chemical Significance

The synthesis of such a multifaceted compound challenges chemists to explore new pathways and methodologies. Chemists may use techniques such as:

  • Modern Organic Synthesis: Advanced strategies offer innovative ways to assemble complex molecules.
  • Structure-Activity Relationship (SAR) Studies: Analyses of how variations in structure can affect biological activity, crucial for drug design.

In summary, 2-[4-phenyl-2-(sulfanylmethyl)butanoyl]imino-2-[5-(tetrazol-1-ylmethyl)-2-thienyl]acetic acid represents a fascinating intersection of chemistry and biology, with its intricate structure inviting broader exploration and potential innovation in therapeutic applications.