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Fenoprofen

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Identification
Molecular formula
C15H14O2
CAS number
31879-05-7
IUPAC name
2-(4-phenylphenyl)butanoic acid
State
State

At room temperature, fenoprofen is in a solid state, appearing as a stable crystalline substance.

Melting point (Celsius)
114.00
Melting point (Kelvin)
387.15
Boiling point (Celsius)
404.80
Boiling point (Kelvin)
677.95
General information
Molecular weight
242.28g/mol
Molar mass
242.2840g/mol
Density
1.0815g/cm3
Appearence

Fenoprofen appears as a white or off-white crystalline powder. It is nearly odorless and is characterized by its crystalline structure.

Comment on solubility

Solubility of 2-(4-phenylphenyl)butanoic acid

2-(4-phenylphenyl)butanoic acid, also known as a non-steroidal anti-inflammatory drug (NSAID), displays interesting solubility characteristics that are important for its bioavailability and pharmacological effects. Understanding its solubility is crucial for effective formulation in pharmaceutical applications. Here are some key points regarding its solubility:

  • Solvent Dependency: This compound tends to be insoluble in water but shows improved solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO).
  • pH Influence: The solubility can vary significantly with pH levels. Generally, requiring an acidic environment can enhance its solubility due to the ionization of the carboxylic acid group.
  • Temperature Effects: Like many organic compounds, increasing temperature may result in higher solubility, which can be particularly beneficial for dissolution processes in pharmacological formulations.
  • Formulation Strategies: To improve solubility, complexation with cyclodextrins or the use of nanoparticle formulations can be considered, enhancing its therapeutic efficacy.

In conclusion, the solubility of 2-(4-phenylphenyl)butanoic acid depends on several factors including the solvent, pH, and temperature. These aspects are critical for scientists to consider during drug formulation and deployment.

Interesting facts

Interesting Facts about 2-(4-phenylphenyl)butanoic Acid

2-(4-phenylphenyl)butanoic acid is a fascinating compound, primarily known for its role in medicinal chemistry and its effects on biological systems. Here are some key highlights about this intriguing molecule:

  • Pharmaceutical Applications: This compound has been studied for its potential use as a non-steroidal anti-inflammatory drug (NSAID). Its structural features may contribute to its ability to inhibit pain and inflammatory responses in the body.
  • Unique Structural Attributes: The compound features a butanoic acid backbone, which is connected to two aromatic phenyl groups. This combination enhances its lipophilicity, potentially impacting its interaction with biological membranes.
  • Synthesis Pathways: Various methods can be employed to synthesize this compound, often involving the Friedel-Crafts reaction to form the phenyl groups, followed by subsequent modifications to introduce the butanoic acid moiety.
  • Research Insights: Studies have suggested that the compound may exhibit anti-cancer properties, making it a subject of interest in oncology research. Its ability to target specific signaling pathways could contribute to the development of targeted therapies.
  • Intermolecular Interactions: The presence of multiple phenyl groups opens possibilities for enhanced π-π stacking interactions. This behavior can influence the compound's solubility and bioavailability in pharmaceutical formulations.

The structural complexity and potential medicinal benefits demonstrate why 2-(4-phenylphenyl)butanoic acid remains a compound of significant interest in chemical and pharmaceutical research. As scientists continue to explore its pathways and mechanisms, we can anticipate exciting advancements in drug development and therapeutic applications.

Synonyms
Xenbucin
Liosol
959-10-4
Liposana
Xenbucina
Xenbucine
2-(4-Biphenylyl)butyric acid
Maggioni 1559
Ethyl-p-xenylacetic acid
Xenbucina [DCIT]
M.G. 1559
Xenbucino
Xenbucinum
Lisol
4-Biphenylylethylacetic acid
4-Diphenylylethylacetic acid
2-(p-Biphenylyl)butyric acid
Xenbucin [USAN:INN]
2-(p-Biphenylyl)butanoic acid
Xenbucine [INN-French]
Xenbucinum [INN-Latin]
Xenbucino [INN-Spanish]
alpha-(p-Xenyl)butyric acid
BUTYRIC ACID, 2-(4-BIPHENYLYL)-
.alpha.-(p-Xenyl)butyric acid
alpha-(4-Biphenylyl)butyric acid
alpha-(4-Diphenylyl)butyric acid
EINECS 213-492-9
MAGGIONI-1559
UNII-R3U09W4H4I
(1',1'-Biphenyl)-4-butanoic acid
NSC 16316
NSC-16316
Xenbucin (USAN)
W 1760
alpha-Ethyl-p-phenyl-alpha-toluic acid
4-Biphenylacetic acid, .alpha.-ethyl-
MG 1559
(4-diphenylyl)ethylacetic acid
BRN 3294506
XENBUFICIN
R3U09W4H4I
Lisol (TN)
(+-)-alpha-Ethyl-4-biphenylacetic acid
Acido alpha-(4-difenilil)butirrico
alpha-Ethyl-(1,1'-biphenyl)-4-acetic acid
XENBUCIN [USAN]
Acido alpha-(4-difenilil)butirrico [Italian]
XENBUCIN [INN]
XENBUCIN [MI]
4-Biphenylacetic acid, alpha-ethyl-
XENBUCIN [MART.]
MG-1559
W-1760
4-09-00-02558 (Beilstein Handbook Reference)
Xenbucine (INN-French)
Xenbucinum (INN-Latin)
Xenbucino (INN-Spanish)
XENBUCIN (MART.)
(1,1'-Biphenyl)-4-acetic acid, alpha-ethyl-
[1,1'-Biphenyl]-4-acetic acid, alpha-ethyl-
(1,1'-BIPHENYL)-4-ACETIC ACID, .ALPHA.-ETHYL-
[1',1'-Biphenyl]-4-butanoic acid
4-Biphenylacetic acid, alpha-ethyl-(8CI)
213-492-9
2-(4-phenylphenyl)butanoic acid
Xenbufin
[1, .alpha.-ethyl-
WLN: QVY2&R DR
SCHEMBL24134
2-(4-Biphenyl)butyric acid
(1,1'-Biphenyl)-4-acetic acid, alpha-ethyl-, (+-)-
CHEMBL2105601
2-(4-Biphenylyl)-butanoic acid
DTXSID80862486
CHEBI:134976
IYEPZNKOJZOGJG-UHFFFAOYSA-N
NSC16316
.alpha.-(4-Biphenylyl)butyric acid
.alpha.-(4-Diphenylyl)butyric acid
.alpha.-Ethyl-4-biphenylacetic acid
AKOS014791389
2-[1,1'-biphenyl]-4-ylbutanoic acid
2-([1,1'-Biphenyl]-4-yl)butanoic acid
(+-)-.alpha.-Ethyl-4-biphenylacetic acid
.alpha.-Ethyl-p-phenyl-.alpha.-toluic acid
NS00042502
D06337
EN300-1868509
(+-)-.alpha.-Ethyl-[1,1'-biphenyl]-4-acetic acid
Q27287758