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2-(4-Prop-2-ynoxyphenyl)ethanehydroxamic acid

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Identification
Molecular formula
C11H11NO3
IUPAC name
2-(4-prop-2-ynoxyphenyl)ethanehydroxamic acid
State
State

This compound is typically found in a solid state at room temperature. It is a crystalline substance, stable under normal conditions.

Melting point (Celsius)
110.00
Melting point (Kelvin)
383.00
Boiling point (Celsius)
420.00
Boiling point (Kelvin)
693.00
General information
Molecular weight
221.25g/mol
Molar mass
221.2500g/mol
Density
1.1740g/cm3
Appearence

2-(4-Prop-2-ynoxyphenyl)ethanehydroxamic acid appears as a white to off-white crystalline solid. The crystals are usually needle-like or granular, depending on the method of crystallization used. It is not significantly hygroscopic under normal conditions, maintaining its form without significant clumping in dry air.

Comment on solubility

Solubility of 2-(4-prop-2-ynoxyphenyl)ethanehydroxamic acid

The solubility of 2-(4-prop-2-ynoxyphenyl)ethanehydroxamic acid can be an intriguing characteristic to explore. This compound is known to exhibit variable solubility across different solvents based on its polar and non-polar regions. Here are some key points regarding its solubility:

  • Water Solubility: Hydroxamic acids tend to have limited solubility in water due to their lipophilic nature, which is influenced by the substituents attached to the aromatic and aliphatic parts of the molecule.
  • Organic Solvents: It is generally more soluble in organic solvents like methanol or ethanol, where the non-polar regions can better interact with the solvent molecules.
  • pH Dependence: The solubility can also be affected by pH levels; for example, it may dissolve better in a basic solution as the hydroxamic acid group can deprotonate, increasing solubility.

In scientific literature, it is often noted that the solubility of such compounds is a crucial factor in determining their bioavailability and efficacy in various applications. As highlighted by various sources, "understanding the solubility profile is essential for optimizing formulation strategies." Therefore, when working with 2-(4-prop-2-ynoxyphenyl)ethanehydroxamic acid, researchers must consider these factors to effectively utilize its potential.

Interesting facts

Interesting Facts about 2-(4-prop-2-ynoxyphenyl)ethanehydroxamic acid

2-(4-prop-2-ynoxyphenyl)ethanehydroxamic acid is a fascinating compound with several intriguing properties and applications. Here are some key points that make this compound noteworthy:

  • Structure & Reactivity: This compound contains a hydroxamic acid functional group, characterized by the presence of both an amine and a hydroxyl group. This unique structure allows it to participate in a variety of chemical reactions and makes it a valuable tool in organic synthesis.
  • Biological Activity: Hydroxamic acids frequently display significant biological activities. Compounds of this class can function as metal chelators and enzyme inhibitors, which could lead to applications in drug design, particularly for cancer therapies and antimicrobial agents.
  • Material Science: Its ability to form chelates with metal ions may find uses in catalysis and material development. The incorporation of triple bonds in the prop-2-ynoxy group enhances its reactivity and potentially opens avenues for creating specialized materials.
  • Research Potential: As a chemist, one might explore how modifying the substituents on the phenyl ring can influence the compound's properties, including its reactivity, selectivity, and biological effectiveness. This exploration could broaden the field of study related to chemical multifunctionality.
  • Environmental Considerations: Like many synthetic compounds, the environmental impact of 2-(4-prop-2-ynoxyphenyl)ethanehydroxamic acid should be carefully evaluated. Its potential biodegradability and effects on ecosystems are important aspects of its overall profile.

In conclusion, 2-(4-prop-2-ynoxyphenyl)ethanehydroxamic acid stands as a prime example of how much potential a single compound can hold. Its novel structure and subsequent reactivities offer exciting avenues for ongoing research and application in various scientific fields.

Synonyms
2-(p-(2-Propynyloxy)phenyl)acetohydroxamic acid
ACETOHYDROXAMIC ACID, 2-(p-(2-PROPYNYLOXY)PHENYL)-
23142-43-0
DTXSID40177720
RefChem:316792
DTXCID00100211
IMMGGYQQWAHCLJ-UHFFFAOYSA-N
N-hydroxy-2-[4-(2-propynyloxy)phenyl]acetamide