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2-(4-propoxyphenyl)ethanehydroxamic acid

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Identification
Molecular formula
C11H15NO3
CAS number
502906-78-1
IUPAC name
2-(4-propoxyphenyl)ethanehydroxamic acid
State
State

This compound is a solid at room temperature.

Melting point (Celsius)
119.00
Melting point (Kelvin)
392.15
Boiling point (Celsius)
327.00
Boiling point (Kelvin)
600.15
General information
Molecular weight
209.25g/mol
Molar mass
208.2650g/mol
Density
1.1671g/cm3
Appearence

The compound 2-(4-propoxyphenyl)ethanehydroxamic acid typically appears as a crystalline solid. The color can vary from white to off-white depending on purity and specific conditions of crystallization.

Comment on solubility

Solubility of 2-(4-propoxyphenyl)ethanehydroxamic acid

The solubility of 2-(4-propoxyphenyl)ethanehydroxamic acid can be somewhat complex due to its chemical structure and functional groups. Here are some key points to consider regarding its solubility:

  • Polar and Nonpolar Interactions: This compound contains both aromatic and hydroxamic acid functional groups, influencing its solubility in different solvents. The presence of the hydroxamic acid group may enhance solubility in polar solvents such as water or methanol.
  • Aromatic Influence: The propoxy and phenyl groups may create a hydrophobic region, which can hinder solubility in highly polar solvents. Therefore, you might observe better solubility in organic solvents like ethanol or dimethyl sulfoxide (DMSO).
  • pH Dependency: The solubility of such compounds can also be pH-dependent. In acidic or basic conditions, the ionization state of the hydroxamic group can change, potentially increasing solubility in aqueous solutions.
  • Temperature Effects: Solubility may improve with an increase in temperature, making it important to consider the specific conditions under which solubility is being evaluated.

As a general guideline, 2-(4-propoxyphenyl)ethanehydroxamic acid may exhibit solubility characteristics similar to other hydroxamic acids, often characterized by moderate solubility in polar organic solvents, yet less so in pure water. Therefore, conducting experimental solubility tests is crucial for precise applications.

Interesting facts

Exploring 2-(4-propoxyphenyl)ethanehydroxamic acid

2-(4-propoxyphenyl)ethanehydroxamic acid is a fascinating compound that resides at the intersection of organic chemistry and medicinal applications. Known for its unique structural features, this compound holds significant promise in various fields.

Key Features

  • Hydroxamic Acid Moiety: The presence of the hydroxamic acid functional group is crucial as it often plays a role in biological activity, particularly in enzyme inhibition.
  • Pharmacological Interest: Compounds like this one are often explored for their potential in drug development, especially in targeting cancer and other diseases due to their ability to modulate biological pathways.
  • Synthetic Versatility: The compound can be synthesized from simpler organic precursors, making it a valuable target for chemists looking to explore structure-activity relationships.

Interesting Uses and Applications

This compound exhibits a variety of potential applications due to its distinctive properties:

  • Utilized in medicinal chemistry for developing anticancer agents.
  • This compound type is often studied for its ability to inhibit certain enzymes, shedding light on metabolic pathways.
  • Researchers often modify the phenyl rings or hydroxamic acid functional groups to optimize biological activity.

Final Thoughts

As scientists continue to explore the exciting world of organics and their derivatives, compounds like 2-(4-propoxyphenyl)ethanehydroxamic acid represent a tantalizing glimpse into what may become significant in therapeutic applications. In the words of renowned chemist Linus Pauling, “The best way to have a good idea is to have a lot of ideas.” This compound encourages us to ponder its potential and inspire future innovations in medicinal chemistry.

Synonyms
2-(p-Propoxyphenyl)acetohydroxamic acid
13363-00-3
BRN 2725105
ACETOHYDROXAMIC ACID, (p-PROPOXY)PHENYL-
DTXSID60158278
DTXCID8080769
N-hydroxy-2-(4-propoxyphenyl)acetamide
SCHEMBL2777642
CHEMBL3184375
KUC110305N
KUC110305N-02
KSC-264-10-1
KSC-264-091-1