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2-(4-pyrrol-1-ylphenyl)acetic acid

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Identification
Molecular formula
C12H11NO2
CAS number
111386-88-4
IUPAC name
2-(4-pyrrol-1-ylphenyl)acetic acid
State
State

At room temperature, 2-(4-pyrrol-1-ylphenyl)acetic acid is generally a solid, with its crystalline structure making it stable under normal conditions.

Melting point (Celsius)
221.50
Melting point (Kelvin)
494.65
Boiling point (Celsius)
451.70
Boiling point (Kelvin)
724.85
General information
Molecular weight
201.22g/mol
Molar mass
201.2240g/mol
Density
1.2423g/cm3
Appearence

The compound typically appears as a white to off-white solid crystalline powder. Its appearance can vary slightly depending on purity and particle size, but it is generally in powder form.

Comment on solubility

Solubility of 2-(4-pyrrol-1-ylphenyl)acetic acid

2-(4-pyrrol-1-ylphenyl)acetic acid is an intriguing compound with notable solubility characteristics. Understanding its solubility can provide insight into its potential applications in various chemical and pharmaceutical contexts.

Solubility in Different Solvents

The solubility of 2-(4-pyrrol-1-ylphenyl)acetic acid can vary significantly depending on the solvent used. Here are some key points to consider:

  • Polar Solvents: The compound is likely to exhibit good solubility in polar solvents due to the presence of the carboxylic acid functional group, which can form hydrogen bonds.
  • Non-Polar Solvents: In non-polar solvents, the solubility may be limited as the hydrophobic sections of the molecule do not interact favorably with non-polar environments.
  • Aqueous Solutions: The solubility in water specifically is influenced by pH, and in acidic conditions, the molecule may dissociate more effectively, enhancing its solubility.

Factors Influencing Solubility

Several factors contribute to the solubility of this compound:

  1. Temperature: Increasing temperature generally aids in solubility for many organic compounds.
  2. Presence of Salt: Salting-out effects can occur, which may reduce solubility in aqueous solutions.
  3. Molecular Structure: The 4-pyrrol-1-yl moiety enhances the compound's ability to interact with solvents, potentially improving solubility in specific situations.

In conclusion, the solubility of 2-(4-pyrrol-1-ylphenyl)acetic acid is complex and variable, highly dependent on solvent type, temperature, and pH. Comprehensive studies and experimentation are essential to accurately determine solubility in various environments.

Interesting facts

Interesting Facts about 2-(4-pyrrol-1-ylphenyl)acetic acid

2-(4-pyrrol-1-ylphenyl)acetic acid, often referred to as a versatile derivative in the field of medicinal chemistry, showcases a fascinating combination of structural features. Below are some compelling insights about this compound:

  • Structural Significance: The presence of the pyrrole ring introduces unique electronic properties that can influence the compound's reactivity and interaction with biological systems.
  • Biological Activity: Compounds containing pyrrole moieties are renowned for their diverse pharmacological effects. 2-(4-pyrrol-1-ylphenyl)acetic acid has been explored for its potential anti-inflammatory and analgesic properties.
  • Synthesis Routes: The synthesis of this compound can be achieved through various chemical reactions, including both classical methods and modern approaches such as microwave-assisted synthesis, showcasing the evolution of synthetic techniques in organic chemistry.
  • Applications in Drug Development: Its structural framework suggests potential applications in drug design, particularly in creating anti-cancer agents or neuromodulators, highlighting its relevance in pharmaceutical research.
  • Research Opportunities: The unique combination of the carboxylic acid and the pyrrole functionality makes this compound an exciting candidate for further studies in medicinal and organic chemistry.

As a student or researcher in chemistry, one can appreciate how the molecular architecture of 2-(4-pyrrol-1-ylphenyl)acetic acid opens up numerous investigational avenues. This compound exemplifies the bridge between structure and activity, underpinning the importance of chemical modifications in developing effective therapeutics. "The design of a molecule can influence its destiny," a mantra that resonates profoundly in the study of such intricate compounds.

Synonyms
22048-71-1
2-(4-(1H-pyrrol-1-yl)phenyl)acetic acid
Benzeneacetic acid, 4-(1H-pyrrol-1-yl)-
4-(1-Pyrryl)phenylacetic acid
2-[4-(1H-pyrrol-1-yl)phenyl]acetic acid
BRN 1620223
(p-(1-Pyrrolyl)phenyl)acetic acid
ACETIC ACID, (p-(1-PYRROLYL)PHENYL)-
Acido 4-(1-pirril)fenilacetco [Italian]
Acido 4-(1-pirril)fenilacetco
DTXSID30176525
5-20-05-00025 (Beilstein Handbook Reference)
RefChem:552008
DTXCID1099016
862-824-4
[4-(1H-pyrrol-1-yl)phenyl]acetic acid
(4-Pyrrol-1-yl-phenyl)-acetic acid
2-(4-pyrrol-1-ylphenyl)acetic acid
MFCD01672789
MLS000716817
N-(4-Carboxymethene)phenylpyrrole
SMR000278334
2-(4-pyrrolylphenyl)acetic acid
Oprea1_211914
cid_30923
CHEMBL258756
SCHEMBL6790414
BDBM79498
4-(1-Pyrrolyl)phenylacetic Acid
HMS1700N11
HMS2630L03
ALBB-023779
SBB011007
STK662061
2-[4-(1-pyrrolyl)phenyl]acetic acid
AKOS000101935
2-(4-pyrrol-1-ylphenyl)ethanoic acid
SB62214
NCGC00242368-02
ST048375
SY082874
TS-02859
2-(4-(1H-pyrrol-1-yl)phenyl)aceticacid
CS-0197030
MLS000716817-02
EN300-36052
VU0292079-2
VU0292079-3
D94926
F059670
Z111572964