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2-(4-tert-butylphenyl)ethanehydroxamic acid

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Identification
Molecular formula
C12H17NO2
CAS number
13806-76-1
IUPAC name
2-(4-tert-butylphenyl)ethanehydroxamic acid
State
State

At room temperature, 2-(4-tert-butylphenyl)ethanehydroxamic acid is typically found in a solid state. This characteristic allows it to be handled and measured easily for use in chemical reactions or applications.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
480.00
Boiling point (Kelvin)
753.15
General information
Molecular weight
221.28g/mol
Molar mass
221.2960g/mol
Density
1.0825g/cm3
Appearence

2-(4-tert-butylphenyl)ethanehydroxamic acid is typically a crystalline solid. The crystal form is often white to off-white and can sometimes appear as a powder depending on the purity and processing conditions.

Comment on solubility

Solubility of 2-(4-tert-butylphenyl)ethanehydroxamic acid

2-(4-tert-butylphenyl)ethanehydroxamic acid is a fascinating compound with unique solubility characteristics that are important for its practical applications. The solubility of this compound can be influenced by several factors:

  • Polar versus Non-Polar Solvents: Due to the presence of the hydroxamic acid functional group, this compound exhibits a *polar* characteristic, which tends to enhance its solubility in polar solvents such as water and alcohols.
  • Temperature: As with many chemical compounds, increasing the temperature can generally enhance solubility. However, the exact temperature dependency may vary based on specific interactions between the solute and solvent.
  • pH Levels: The solubility may also vary with changes in pH; the ionization of the hydroxamic acid group can play a significant role in its interaction with different solvents.
  • Concentration: Concentration gradients can affect solubility, sometimes leading to saturation, where no more solute can dissolve in the solvent.

In summary, while 2-(4-tert-butylphenyl)ethanehydroxamic acid shows potential for solubility in polar solvents owing to its functional groups, its solubility profile is complex and influenced by factors such as temperature, pH, and concentration. It is essential to consider these factors when working with this compound in various applications, as they can significantly impact its reactivity and overall performance.

Interesting facts

Interesting Facts about 2-(4-tert-butylphenyl)ethanehydroxamic acid

2-(4-tert-butylphenyl)ethanehydroxamic acid, an organic compound, is notable for its intriguing structural characteristics and potential applications. Here are some engaging aspects of this compound:

  • Versatile Derivative: This compound belongs to a class of hydroxamic acids, which are widely recognized for their ability to chelate metal ions. This property makes them useful in fields such as biochemistry and medicinal chemistry.
  • Drug Development: Hydroxamic acids, including this compound, have been researched in the context of therapeutic agents, particularly as inhibitors for certain enzymes, such asmatrix metalloproteinases (MMPs). These enzymes play critical roles in various physiological processes as well as in disease progression, including cancer metastasis.
  • Structure-Activity Relationship: Understanding the effects of the tert-butyl group’s position and sterics on biological activity provides a fascinating case study for chemists. The bulky substituent can impact the compound's solubility and interaction with biological targets, making it a prime candidate for structure-activity relationship (SAR) studies.
  • Historical Significance: Hydroxamic acids have a rich history in chemistry, with initial discoveries paving the way for advancements in organic synthesis and drug discovery. This particular compound is an example of how modifications to fundamental structures can lead to novel functionalities.
  • Research Potential: Ongoing research into hydroxamic acids is promising, especially regarding their use in treating diseases through targeted therapies. Scientists continue to explore the potential of such compounds to enhance effectiveness and minimize side effects in drug formulations.

"The more we understand about these unique compounds, the more opportunities arise for innovation in chemical applications."

In summary, 2-(4-tert-butylphenyl)ethanehydroxamic acid represents just one of many compounds exhibiting the intricate balance of chemistry and biology, holding the potential for significant contributions to science and medicine.

Synonyms
2-(p-tert-Butylphenyl)acetohydroxamic acid
3289-00-7
BRN 2213421
ACETOHYDROXAMIC ACID, 2-(p-tert-BUTYLPHENYL)-
DTXSID50186540
DTXCID90109031
SCHEMBL15581376