Tiapride | Solubility of Things

Identification

Molecular formula

C₁₉H₂₆N₂O₄S

CAS number

51037-30-0

IUPAC name

2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone

State

At room temperature, Tiapride is usually in a solid state.

Melting point (Celsius)

318.00

Melting point (Kelvin)

591.15

Boiling point (Celsius)

573.15

Boiling point (Kelvin)

300.00

General information

Molecular weight

381.49g/mol

Molar mass

381.4700g/mol

Density

1.2250g/cm³

Appearence

Tiapride typically appears as a white or off-white crystalline powder.

Comment on solubility

Solubility of 2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone

The solubility of 2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone is an important factor to consider in its applications and effectiveness. This compound, with its unique structure that includes a thiazole ring and a piperazine moiety, exhibits distinctive solubility characteristics.

Key Factors Influencing Solubility:

Polarity: The presence of polar functional groups, such as methoxy groups, can enhance solubility in polar solvents.
Hydrogen Bonding: Potential hydrogen bonding interactions with solvents can impact solubility, often leading to increased dissolution rates.
Molecular Weight: The relatively high molecular weight of this compound might hinder solubility in certain solvents.

Quotes from solubility studies suggest that:

"Solubility is not merely a function of the structural features, but also hinges on the environment or the medium in which the compound is placed."

Generally, 2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone is expected to have moderate solubility in organic solvents like ethanol and dimethyl sulfoxide (DMSO), while its solubility in water may be limited due to the hydrophobic nature of the aromatic components. Understanding its solubility profile is crucial for optimizing formulations and enhancing bioavailability in therapeutic applications.

Interesting facts

Interesting Facts about 2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone

This compound, known for its intriguing structure, plays a pivotal role in the field of medicinal chemistry. Here are some fascinating aspects about this compound:

Diverse Applications: The compound is investigated for its potential use in therapeutics, particularly in the treatment of neurological disorders. Its unique substituents suggest possible interaction with various biological targets.
Structural Features: The 4-thiazol-2-ylpiperazin-1-yl moiety introduces significant biological activity. Thiazoles are known for their role in pharmaceuticals due to their antimicrobial and anti-inflammatory properties.
Mechanism of Action: Preliminary studies suggest that the compound may influence neurotransmitter systems. By acting on serotonin and dopamine receptors, it could potentially modify mood and cognition, making it a candidate for antidepressants.
Synthetic Pathways: The synthesis of this compound typically involves multi-step processes, showcasing the creativity and complexity involved in organic chemistry. It pushes the boundaries of synthetic techniques while providing valuable insights into reaction mechanisms.
Research Potential: This compound serves as a template for further structural modifications. Scientists are keen to explore how slight alterations can enhance efficacy, reduce side effects, or improve pharmacokinetics.

In conclusion, 2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone stands as a beacon of innovation within medicinal chemistry, embodying the essence of design and function in drug development. With ongoing research, its full potential may unravel new therapeutic pathways.