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Lomerizine Dihydrochloride

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Identification
Molecular formula
C21H27Cl2N3O4S
CAS number
101477-54-7
IUPAC name
2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone;dihydrochloride
State
State

At room temperature, lomerizine dihydrochloride is typically in a solid state.

Melting point (Celsius)
238.00
Melting point (Kelvin)
511.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
437.44g/mol
Molar mass
437.3640g/mol
Density
1.3000g/cm3
Appearence

Lomerizine dihydrochloride appears as a white to off-white crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone;dihydrochloride

The solubility of 2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride can be characterized by various factors influenced by its chemical structure. Here are some key points to consider:

  • Polarity: The presence of multiple methoxy groups can enhance the polarity of this compound, suggesting that it may display good solubility in polar solvents such as water and alcohols.
  • Hydrochloride Form: As a dihydrochloride salt, this compound is likely to be more soluble in aqueous solutions compared to its non-salt form due to ionization.
  • Temperature Effects: Solubility can increase with temperature; hence, higher temperatures might enhance the dissolution of this compound in solvents.
  • pH Consideration: The solubility might vary in acidic vs. neutral environments, so the pH of the solution can significantly impact its solubility behaviour.

In conclusion, while the exact solubility of this compound is dependent on specific environmental conditions, one could generally expect enhanced solubility in polar solvents and at elevated temperatures due to its salt form and molecular structure. As always, specific experimental data would provide the most accurate insight into its solubility characteristics.

Interesting facts

Interesting Facts about 2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride

This intriguing compound has garnered attention in various fields, particularly in medicinal chemistry. Here are some fascinating facts:

  • Pharmaceutical Potential: The compound is notable for its potential therapeutic applications, particularly in the development of new drugs targeting central nervous system disorders.
  • Structure-Activity Relationship: The unique combination of a thiazole ring and a piperazine moiety suggests that it could interact with neurotransmitter systems in the brain, making it a subject of interest for researchers aiming to modulate activity in these pathways.
  • Mechanism of Action: While specific mechanisms are still being explored, compounds with similar structures have been noted for their ability to act as inhibitors or modulators, potentially leading to advancements in the treatment of anxiety and depression.
  • Richer than it Appears: With its multiple methoxy groups on the phenyl ring, this compound showcases how *small structural variations can lead to significant biological differences*, an essential concept in drug design.
  • Piperazine Derivatives: Piperazine itself is a well-studied scaffold in medicinal chemistry, often associated with a variety of pharmacological effects, including anti-anxiety and anti-depressive activities.
  • Research Opportunities: The compound invites further research to investigate its full profile of effects, including efficacy and safety, providing fertile ground for students and scientists alike to explore.

In summary, 2-(4-thiazol-2-ylpiperazin-1-yl)-1-(3,4,5-trimethoxyphenyl)ethanone; dihydrochloride represents an exciting intersection of chemistry and pharmacology. Its complex structure and promising biological activity make it a valuable piece in the puzzle of drug discovery.

Synonyms
Acetophenone, 2-(4-(2-thiazolyl)piperazinyl)-3',4',5'-trimethoxy-, dihydrochloride
17755-67-8
DTXSID00170333
1-(2-Thiazolyl)-4-(3,4,5-trimethoxybenzoylmethyl)piperazine dihydrochloride
2-(4-(2-Thiazolyl)piperazinyl)-3',4',5'-trimethoxyacetophenone dihydrochloride
Piperazine, 1-(2-thiazolyl)-4-(3,4,5-trimethoxybenzoylmethyl)-, dihydrochloride
DTXCID5092824
2-[4-(1,3-thiazol-2-yl)piperazin-1-yl]-1-(3,4,5-trimethoxyphenyl)ethanone dihydrochloride