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Oxymetazoline

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Identification
Molecular formula
C16H19F3N2
CAS number
1491-59-4
IUPAC name
2-[[4-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole
State
State
At room temperature, oxymetazoline is typically in a solid state. It is often formulated into a solution for medical use.
Melting point (Celsius)
141.00
Melting point (Kelvin)
414.15
Boiling point (Celsius)
392.30
Boiling point (Kelvin)
665.45
General information
Molecular weight
260.34g/mol
Molar mass
260.2970g/mol
Density
1.1360g/cm3
Appearence

Oxymetazoline is a white to off-white crystalline powder. It is typically odorless and is used in various formulations, primarily in nasal sprays for its vasoconstricting properties.

Comment on solubility

Solubility of 2-[[4-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole

The solubility of the compound 2-[[4-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole is an interesting topic due to its unique structure and the functional groups involved. Here are some key aspects to consider:

  • Polarity: The presence of the trifluoromethyl group often enhances the polarity of the molecule, which can affect its interactions with solvents.
  • Solvent Compatibility: This compound may exhibit different solubility profiles in various solvents. Common solvents to explore include:
    • Polar solvents (e.g., water, methanol)
    • Apolar solvents (e.g., hexane, toluene)
  • Crystallization: The crystalline form of the compound can also influence solubility, with different polymorphs potentially exhibiting varied solubility characteristics.
  • Temperature Effect: Solubility can increase with temperature; hence, it is essential to consider temperature when assessing the solubility of this compound.

In conclusion, while the solubility of 2-[[4-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole may be complex and varies with solvent and conditions, investigating its interactions can lead to valuable insights in chemical applications.

Interesting facts

Interesting Facts about 2-[[4-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole

This fascinating compound, often referred to for its unique structure and properties, is a member of the imidazole family, which is notable for its diverse roles in both synthetic chemistry and biological systems. Here are some noteworthy aspects:

  • Structural Diversity: The compound features a 4-(trifluoromethyl)phenyl group, which introduces significant electronic effects due to the electronegative fluorine atoms. This can influence the reactivity and stability of the compound in various chemical environments.
  • Biological Relevance: Imidazole derivatives are widely recognized for their presence in numerous biological molecules, including histidine and important pharmacological agents. Thus, understanding compounds like this could have implications in medicinal chemistry.
  • Fluorine's Influence: The presence of trifluoromethyl groups enhances the lipophilicity of the compound, which often leads to increased biological activity and bioavailability in pharmaceutical applications. This has made such compounds crucial for drug design.
  • Potential Applications: Given their unique pharmacophoric features, compounds with imidazole structures are actively researched for their potential applications in fungicides, antibacterial agents, and other therapeutic areas.
  • Synthetic Pathways: The synthesis of this compound can involve various pathways including but not limited to Michael addition reactions or even cycloaddition mechanisms, highlighting its versatility in organic synthesis.

"In the realm of chemical compounds, the interplay of structure and function results in an endless frontier of possibilities."

For chemists and researchers alike, exploring compounds like 2-[[4-(trifluoromethyl)phenyl]methyl]-4,5-dihydro-1H-imidazole enriches not only our knowledge of chemical diversity but also bolsters our ability to innovate in various scientific fields.

Synonyms
3038-60-6
BRN 0915364
2-IMIDAZOLINE, 2-(p-TRIFLUOROMETHYLBENZYL)-
2-(p-Trifluoromethylbenzyl)-2-imidazoline
DTXSID90184464
DTXCID00106955
5-23-07-00012 (beilstein handbook reference)