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Triflupromazine

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Identification
Molecular formula
C9H10F3N3
CAS number
51481-99-7
IUPAC name
2-[[4-(trifluoromethyl)phenyl]methyl]guanidine
State
State

At room temperature, the compound is typically in a solid state.

Melting point (Celsius)
154.00
Melting point (Kelvin)
427.15
Boiling point (Celsius)
481.90
Boiling point (Kelvin)
755.05
General information
Molecular weight
279.27g/mol
Molar mass
279.2730g/mol
Density
1.2720g/cm3
Appearence

The compound typically appears as a white, crystalline powder. It is not soluble in water and has characteristic aromatic properties due to its phenyl group.

Comment on solubility

Solubility of 2-[[4-(trifluoromethyl)phenyl]methyl]guanidine

The solubility of 2-[[4-(trifluoromethyl)phenyl]methyl]guanidine can be influenced by several factors, primarily due to its unique chemical structure.

In general, guanidine derivatives display varied solubility profiles based on their molecular composition. For 2-[[4-(trifluoromethyl)phenyl]methyl]guanidine, consider the following aspects:

  • Polarity: The presence of the trifluoromethyl group may enhance the hydrophobic characteristics, potentially reducing solubility in polar solvents like water.
  • Non-polar Solvents: This compound is likely to show greater solubility in non-polar solvents such as hexane or chloroform due to its hydrophobic components.
  • Temperature Effects: As with many organic compounds, increased temperatures may facilitate solubility in both polar and non-polar solvents.
  • pH Dependency: The solubility could also vary with pH changes, as guanidine derivatives may behave differently in acidic or basic environments.

In summary, the solubility of 2-[[4-(trifluoromethyl)phenyl]methyl]guanidine likely reflects its intricate balance between polar and non-polar characteristics. Thus, it is essential to experiment with various solvents and conditions to obtain a complete understanding of its solubility behavior.

Interesting facts

Interesting Facts About 2-[[4-(trifluoromethyl)phenyl]methyl]guanidine

2-[[4-(trifluoromethyl)phenyl]methyl]guanidine is a noteworthy compound in the realm of organic chemistry, particularly due to its unique structure and a range of intriguing applications. Here are some compelling points about this compound:

  • Structure and Characteristics: The presence of the trifluoromethyl group (−CF3) significantly enhances the compound's properties. This group is known for its ability to influence the electronic characteristics, leading to increased lipophilicity and metabolic stability.
  • Role in Pharmaceuticals: This compound is of particular interest in pharmaceutical chemistry, as derivatives of guanidine are often studied for their potential as drug candidates. They may exhibit properties that can be beneficial in treating various conditions.
  • Biological Activity: Research has shown that guanidine derivatives can possess diverse biological activities, including antibacterial, antiviral, and anti-inflammatory effects. These properties make them valuable in medicinal chemistry.
  • Research Applications: Scientists are continually exploring the interactions of this compound with various biological systems. Its ability to serve as a ligand in coordination chemistry enhances its significance in studies involving metal complexes.
  • Synthetic Routes: The synthesis of this compound often involves multi-step organic reactions, showcasing the creativity and skill required in organic synthesis methodologies.
  • Environmental Considerations: With its trifluoromethyl group, understanding the environmental impact of the compound is crucial, especially in the context of sustainability and regulatory guidelines related to fluorinated compounds.

As you delve deeper into the world of 2-[[4-(trifluoromethyl)phenyl]methyl]guanidine, remember the importance of studying compounds not just for their chemical properties, but also for their potential to contribute to advancements in science and medicine. The quote "Chemistry is the scientific study of the properties and behavior of matter" resonates well with the exploration of such fascinating compounds.

Synonyms
1-(4-Trifluoromethylbenzyl)guanidine
14629-39-1
1-(4-(Trifluoromethyl)benzyl)guanidine
1-[4-(Trifluoromethyl)benzyl]guanidine
CHEMBL466430
SCHEMBL4020664
XMMKZZRJMIIBED-UHFFFAOYSA-N
MFCD17242179
AKOS011695476
SY340576