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Clonidine

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Identification
Molecular formula
C9H9Cl2N4
CAS number
4205-91-8
IUPAC name
2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine
State
State

Clonidine, at room temperature, is typically in a solid state. Due to its crystalline powder form, it remains solid until reaching its melting point.

Melting point (Celsius)
142.00
Melting point (Kelvin)
415.15
Boiling point (Celsius)
312.00
Boiling point (Kelvin)
585.15
General information
Molecular weight
230.09g/mol
Molar mass
230.3350g/mol
Density
1.1900g/cm3
Appearence

Clonidine typically appears as a white to off-white crystalline powder. The compound is odorless and has a bitter taste.

Comment on solubility

Solubility Characteristics of 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine

The solubility of 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine can be quite intriguing due to its complex structure and functional groups.

Factors Influencing Solubility

Some of the critical factors that affect the solubility of this compound include:

  • Polarity: The presence of sulfur and nitrogen atoms suggests a level of polarity in the molecule, which can enhance solubility in polar solvents like water.
  • Hydrophobic Regions: The diethyl groups contribute hydrophobic characteristics, potentially limiting solubility in aqueous environments.
  • Hydrogen Bonding: The imidazole ring can participate in hydrogen bonding, which may improve solubility in polar solvents but complicate solubility in nonpolar media.
  • pH Sensitivity: The compound's solubility may vary significantly with changes in pH, as protonation of the imidazole group can influence the overall charge and thus its interaction with solvents.

Solubility Insights

From the above factors, it is reasonable to expect that:

  • This compound may be more soluble in polar solvents than in nonpolar ones due to its polar functional groups.
  • Solubility could be enhanced in aqueous solutions when the pH is within a certain range, facilitating interactions through hydrogen bonding.
  • Conversely, the presence of the diethyl groups may result in limited solubility in certain organic solvents, depending on their polarity.

In summary, while exact solubility data may vary, the interplay of structural components suggests that 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine is likely to exhibit moderate solubility in polar environments, thus warranting consideration in solvent selection for practical applications.

Interesting facts

Interesting Facts about 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine

This intriguing compound, known for its complex structure, presents a fascinating area of study in organic chemistry. The essential features include a diethylamino group and an imidazoline derivative, which collectively offer a wide range of potential applications in various fields:

  • Pharmaceutical Relevance: The imidazole ring is known for its presence in several biologically active compounds, including antifungal and anti-inflammatory medications. Researchers continue to explore the therapeutic potentials of imidazole derivatives.
  • Structure-Activity Relationship (SAR): Understanding how the modifications in its structure affect biological activity can provide insights into the design of new drugs. The presence of the sulfanyl group can significantly influence the compound's reactivity and pharmacokinetics.
  • Catalytic Applications: Compounds featuring imidazole moieties are often utilized as catalysts in various chemical reactions due to their ability to stabilize transition states and facilitate electron transfer processes.
  • Research on Molecular Interactions: The unique binary moieties in this compound can be beneficial in studying interactions with biological macromolecules, helping scientists understand enzyme mechanisms and receptor binding.

Moreover, the exploration of similar compounds may lead to the development of innovative materials, contributing to advancements in areas such as nanotechnology and materials science.

A quote that resonates with the journey of exploring such compounds is: "Science is a way of thinking much more than it is a body of knowledge." - Carl Sagan This perfectly captures the excitement inherent in the study of chemical compounds like 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine, underscoring its significance in advancing our understanding of chemistry.