Skip to main content

Clonidine

ADVERTISEMENT
Identification
Molecular formula
C9H16Cl3N3S
CAS number
4205-91-8
IUPAC name
2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine;dihydrochloride
State
State
At room temperature, clonidine dihydrochloride is typically a solid. It exists as a crystalline powder, which, owing to its hygroscopic nature, may absorb moisture from the environment.
Melting point (Celsius)
251.00
Melting point (Kelvin)
524.15
Boiling point (Celsius)
220.00
Boiling point (Kelvin)
493.15
General information
Molecular weight
285.22g/mol
Molar mass
285.2150g/mol
Density
1.1600g/cm3
Appearence
Clonidine dihydrochloride appears as a white to off-white crystalline powder. It is soluble in water and alcohol, which makes it suitable for oral administration in solution form.
Comment on solubility

Solubility of 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine; dihydrochloride

The compound 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine; dihydrochloride demonstrates interesting solubility characteristics largely influenced by its dihydrochloride salt form.

Key Points on Solubility:

  • Water Solubility: As a dihydrochloride salt, this compound is generally highly soluble in water. The presence of the hydrochloride groups enhances its ability to interact with water molecules.
  • Polar Solvents: It exhibits good solubility in polar organic solvents. Solvents like methanol or ethanol can dissolve this compound effectively.
  • Non-Polar Solvents: The compound is expected to have low solubility in non-polar solvents such as hexane or benzene. Its polar functional groups limit interaction with non-polar environments.
  • Temperature Dependency: Solubility may vary with temperature changes, typically increasing at higher temperatures, which is common for many ionic compounds.

Understanding the solubility behavior of this compound is crucial for its applications, as it affects its bioavailability and interaction in various chemical environments. In summary, the dihydrochloride form substantially enhances the solubility in aqueous solutions and polar solvents while being less favorable in non-polar conditions.

Interesting facts

Interesting Facts About 2-(4,5-Dihydro-1H-imidazol-2-ylsulfanyl)-N,N-diethyl-ethanamine; Dihydrochloride

This compound is a fascinating example of a synthetic organic molecule with potential biological activity. It features a unique structure that incorporates an imidazole ring, which is known for its presence in many biologically important compounds. Here are some engaging aspects of this compound:

  • Biological Relevance: Compounds with imidazole groups are often found in pharmaceuticals. They can serve as key components in the design of new drugs, particularly in the fields of antimicrobial and antifungal medicinal chemistry.
  • Sulfanyl Group: The presence of the sulfanyl group (–S–) is significant as it can enhance the compound's solubility and reactivity, thus broadening its potential applications. Sulfur-containing compounds have been known to exhibit a variety of biological activities.
  • Diethylamine Component: The diethylamine moiety contributes to the compound's steric and electronic properties, which can influence its affinity for biological targets. It may also play a role in the compound's mechanism of action.
  • Research Potential: Ongoing research into similar compounds continues to reveal their diverse roles in medicine and pharmacology. Exploring structure-activity relationships (SAR) can lead to the development of more effective therapeutic agents.

This compound serves as a vivid illustration of how organic chemistry serves as a platform for innovation in drug design and development. As scientists continue to delve into the intricate properties of such compounds, they unveil new possibilities for treatments that could potentially improve lives.

Synonyms
17124-75-3
2-IMIDAZOLINE, 2-((2-(DIETHYLAMINO)ETHYL)THIO)-, DIHYDROCHLORIDE
2-(2-Diethylaminoethylmercapto)imidazoline chloride hydrochloride
2-((2-(Diethylamino)ethyl)thio)-2-imidazoline dihydrochloride
DTXSID20169042
DTXCID3091533