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Histamine

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Identification
Molecular formula
C5H9N3S
CAS number
51-45-6
IUPAC name
2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)ethanamine
State
State

At room temperature, histamine is typically a hygroscopic solid. While it is stable under normal conditions, when exposed to moisture, it tends to absorb water from the atmosphere, eventually forming a liquid solution.

Melting point (Celsius)
84.00
Melting point (Kelvin)
357.15
Boiling point (Celsius)
267.50
Boiling point (Kelvin)
540.65
General information
Molecular weight
111.16g/mol
Molar mass
111.1570g/mol
Density
1.1690g/cm3
Appearence

Histamine is a colorless hygroscopic solid. It can form crystals in its solid state, and in the presence of light, the compound is known to decompose, resulting in a yellowish discoloration. When dissolved, it forms a colorless aqueous solution.

Comment on solubility

Solubility of 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)ethanamine

The compound 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)ethanamine exhibits interesting solubility characteristics that are influenced by its structural features. Understanding its solubility is essential for applications in pharmaceuticals and chemical synthesis.

Solubility Characteristics:

  • Polar vs. Non-Polar: Given the presence of both amine and imidazole functional groups, this compound tends to be polar, enhancing its solubility in polar solvents such as water and alcohols.
  • Hydrogen Bonding: The ability of 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)ethanamine to form hydrogen bonds facilitates its dissolution in aqueous environments.
  • Temperature Dependence: Like many organic compounds, its solubility may vary with temperature changes - generally, higher temperatures can improve solubility.
  • Concentration: At higher concentrations, there might be variations in solubility due to possible intermolecular interactions that can lead to precipitation.

In conclusion, it can be said that the solubility of 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)ethanamine in various solvents is a crucial factor contributing to its utility in chemical applications. As with many compounds, understanding the nuances of its solubility behavior can pave the way for optimized use in formulation and synthesis.

Interesting facts

Interesting Facts about 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)ethanamine

2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)ethanamine is a fascinating compound that showcases the intricate chemistry of nitrogen and sulfur heterocycles. This compound includes a unique imidazole ring which is known for its versatile reactivity and presence in numerous biological molecules.

Key Characteristics

  • Imidazole Derivative: The imidazole ring contributes significantly to the compound's stability and reactivity. Compounds incorporating this ring are often found in biologically active molecules, such as histidine, an essential amino acid.
  • Functional Groups: The presence of the thioether group (-S-) makes this compound a potential candidate for exploring various chemical reactions and applications in medicinal chemistry.
  • Biological Relevance: Compounds with sulfur and nitrogen functionalities are crucial in the development of pharmaceuticals, particularly as starting points for synthesizing drugs that interact with biological systems.

Potential Applications

This compound can be explored for several applications:

  • Medicinal Chemistry: Its structure may lead to interesting pharmacological properties, making it worthwhile for drug design.
  • Catalysis: Due to the unique electronic properties of sulfur, it may act as a competent catalyst in various reactions.
  • Research: Used in studying biochemical pathways, particularly those related to nitrogen and sulfur metabolism.

In summary, 2-(4,5-dihydro-1H-imidazol-2-ylsulfanyl)ethanamine is not just an ordinary compound; it's a gateway to understanding complex chemical behaviors and their implications in biological systems. By exploring its reactivity and potential applications, researchers can unlock new avenues in the field of chemistry and pharmacology.

Synonyms
AKOS006222740