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Kanamycin A

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Identification
Molecular formula
C18H36N4O11
CAS number
59-01-8
IUPAC name
2-[4,6-diamino-3-[[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxy-cyclohexoxy]-5-methyl-4-(methylamino)tetrahydropyran-3,5-diol
State
State

At room temperature, Kanamycin A is in a solid state. It is commonly stored as a powder, which can then be dissolved in water or other solvents for use in various applications.

Melting point (Celsius)
255.00
Melting point (Kelvin)
528.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
582.59g/mol
Molar mass
582.5880g/mol
Density
1.7250g/cm3
Appearence

Kanamycin A is typically a white or off-white powder. It can also be found in crystalline form. The compound is hygroscopic, meaning it can absorb moisture from the air, which may alter its physical appearance over time.

Comment on solubility

Solubility of 2-[4,6-Diamino-3-[[3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-2-hydroxy-cyclohexoxy]-5-methyl-4-(methylamino)tetrahydropyran-3,5-diol (C18H36N4O11)

The solubility profile of this complex compound is influenced by several contributing factors, primarily due to its intricate molecular structure that includes multiple functional groups. When analyzing solubility, it's crucial to consider:

  • Polarity: The presence of numerous amino and hydroxyl groups suggests that the compound is likely to exhibit high polarity, which generally increases solubility in polar solvents like water.
  • Hydrogen Bonding: With multiple sites available for hydrogen bonding, this compound can interact favorably with water molecules, enhancing its solubility in aqueous environments.
  • Molecular Size: The relatively large molecular weight and size may impede solubility to some extent, as larger molecules often have lower solubility in polar solvents.
  • Saturated vs. Unsaturated: The presence of saturated and unsaturated bonds might also affect how the compound interacts with solvents, potentially favoring solubility in certain organic solvents.

In conclusion, while this compound displays characteristics that may favor its solubility in polar solvents due to its functional groups, empirical testing is essential to fully understand its solubility behavior under various conditions. As a general guideline, "the more functional groups that can participate in interactions with solvent molecules, the higher the likelihood of solubility."


Further investigations should include testing solubility in different solvents and at varying temperatures to establish precise solubility data.

Interesting facts

Interesting Facts about 2-[4,6-Diamino-3-[[3-Amino-6-(Aminomethyl)-3,4-Dihydro-2H-Pyran-2-Yl]Oxy]-2-Hydroxy-Cyclohexoxy]-5-Methyl-4-(Methylamino)Tetrahydropyran-3,5-Diol

This compound is a complex organic molecule that showcases the fascinating interplay of structure and function in medicinal chemistry. Its intricate design highlights elements that are significant in biological systems, particularly in pharmacology.

Key Attributes:

  • Amino groups: The presence of multiple amino groups in its structure is vital for its interactions with biological targets, such as enzymes and receptors.
  • Tetrahydropyran moiety: This structural element enhances the compound's stability and solubility, increasing its potential as a pharmaceutical agent.
  • Cyclohexane derivative: The cyclohexoxy section contributes to its conformational flexibility, which can be crucial for binding to biomolecules.

Moreover, the compound's capability to form hydrogen bonds due to its hydroxyl and amino groups can significantly influence its biological activity and pharmacokinetics. As noted by chemists, "the geometry of a compound can dictate its properties and potential interactions." This makes the study of such compounds essential in drug discovery and development.

Research applications: The complexity and diversity of functionalities present within this compound open up avenues for exploring its role in therapeutic settings, particularly as a potential scaffold for drug synthesis aimed at treating various diseases.

Overall, the multifaceted characteristics of this molecule underscore the beauty and complexity inherent in organic chemistry, illustrating how even a single compound can possess varied properties that lead to significant implications in science and medicine.

Synonyms
4,6-diamino-3-{[3-amino-6-(aminomethyl)-3,4-dihydro-2h-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-c-methyl-3-(methylamino)pentopyranoside
Sisomicin sulfate
NCGC00181169-01
Prestwick0_000506
Prestwick1_000506
Prestwick2_000506
SPBio_002352
CHEMBL115339
SCHEMBL16090396
DTXSID40860468
MCC3470
STK249709
AKOS022067890
NCI60_001521
BRD-A29840884-001-01-2