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Flupirtine

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Identification
Molecular formula
C15H17FN4
CAS number
56995-20-1
IUPAC name
2-(4,6-dimethylpyrimidin-2-yl)-1-(4-fluorophenyl)guanidine
State
State
Flupirtine is a solid at room temperature, typically encountered in its powdered form.
Melting point (Celsius)
117.00
Melting point (Kelvin)
390.00
Boiling point (Celsius)
320.00
Boiling point (Kelvin)
593.00
General information
Molecular weight
318.35g/mol
Molar mass
318.3470g/mol
Density
1.2700g/cm3
Appearence
Flupirtine appears as a crystalline powder.
Comment on solubility

Solubility of 2-(4,6-dimethylpyrimidin-2-yl)-1-(4-fluorophenyl)guanidine

The solubility of 2-(4,6-dimethylpyrimidin-2-yl)-1-(4-fluorophenyl)guanidine can be described as rather complex, influenced by its functional groups and molecular structure. As a guanidine derivative, it is expected to have varying solubility in different solvents.

Factors Influencing Solubility:

  • Polarity: The presence of polar functional groups, such as the guanidine component, generally increases solubility in polar solvents, particularly water.
  • Non-polar regions: The 4-fluorophenyl group introduces some non-polar characteristics, suggesting it may also dissolve in organic solvents like dichloromethane or ethyl acetate.
  • Hydrogen bonding: The ability to form hydrogen bonds with solvent molecules often enhances solubility in polar solvents.

In summary, 2-(4,6-dimethylpyrimidin-2-yl)-1-(4-fluorophenyl)guanidine is likely to exhibit solubility that varies significantly with the choice of solvent:

  • Highly soluble: In polar solvents (e.g., water, methanol)
  • Moderately soluble: In moderately polar solvents (e.g., ethanol, acetone)
  • Low solubility: In non-polar solvents (e.g., hexane)

This multifaceted solubility profile underscores the importance of solvent selection when working with this compound in both laboratory and industrial applications.

Interesting facts

Interesting Facts About 2-(4,6-Dimethylpyrimidin-2-yl)-1-(4-fluorophenyl)guanidine

This intriguing compound belongs to the class of guanidines, which are known for their diverse applications in biological, medicinal, and synthetic chemistry. Known for their unique structure, the presence of a pyrimidine ring and a fluorophenyl group in the molecular composition enhances the compound's pharmacological properties and reactivity.

Key Features:

  • Pyrimidine Inclusion: The pyrimidine moiety contributes to the compound's ability to mimic nucleobases, making it potentially useful in pharmaceutical research.
  • Fluorine Atom Significance: The fluorine atom incorporated into the structure can influence biological activity and solubility, increasing the compound’s effectiveness in targeting specific sites in biological systems.
  • Dimethyl Substituents: The presence of 4,6-dimethyl substituents on the pyrimidine ring suggests the possibility of altering electron density, which could enhance the binding affinity of the compound with various biological substrates.

Researchers are particularly interested in compounds like 2-(4,6-dimethylpyrimidin-2-yl)-1-(4-fluorophenyl)guanidine due to their potential in developing new therapeutic agents. Its structural complexity and unique chemical features can lead to breakthroughs in drug design and delivery systems.

Applications and Potential:

  • Medicinal Chemistry: This compound may show promise in treating various diseases due to its structural versatility.
  • Antimicrobial Properties: Studies have suggested that guanidine derivatives can possess antimicrobial activity, making this compound a subject of interest in the field of infectious diseases.
  • Cardiovascular Research: Some guanidines are being explored for their roles in modulating cardiovascular functions, which emphasizes the need for compounds like this one.

In conclusion, 2-(4,6-dimethylpyrimidin-2-yl)-1-(4-fluorophenyl)guanidine exemplifies how intricate organic structures serve as a foundation for innovation in the chemical and biological sciences. Its potential implications in various fields make it a valuable compound for continued research and exploration.

Synonyms
N-(4,6-dimethylpyrimidin-2-yl)-N'-(4-fluorophenyl)guanidine
1-(4,6-dimethylpyrimidin-2-yl)-3-(4-fluorophenyl)guanidine
1-(4,6-Dimethyl-2-pyrimidinyl)-3-(p-fluorophenyl)guanidine
N'-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N-(4-FLUOROPHENYL)GUANIDINE
H32202
1-(4,6-Dimethyl-2-Pyrimidinyl)-3-(4-Fluorophenyl)Guanidine