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Sunitinib

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Identification
Molecular formula
C22H27FN4O2.HCl
CAS number
341031-54-7
IUPAC name
2-(4,6-dimethylpyrimidin-2-yl)-1-(4-iodophenyl)guanidine
State
State

At room temperature, sunitinib is typically in a solid state. It usually exists as a fine crystalline powder, stable under standard storage conditions typical of pharmaceutical compounds.

Melting point (Celsius)
174.50
Melting point (Kelvin)
447.70
Boiling point (Celsius)
374.50
Boiling point (Kelvin)
647.70
General information
Molecular weight
398.32g/mol
Molar mass
398.3200g/mol
Density
1.5200g/cm3
Appearence

Sunitinib is typically an odorless, yellow to orange crystalline powder. Its precise texture and color may vary slightly based on specific manufacturing processes and environmental conditions.

Comment on solubility

Solubility of 2-(4,6-dimethylpyrimidin-2-yl)-1-(4-iodophenyl)guanidine

The solubility of 2-(4,6-dimethylpyrimidin-2-yl)-1-(4-iodophenyl)guanidine can be influenced by several factors, reflecting its chemical structure and molecular interactions. Here are some key points:

  • Polarity: Due to the presence of guanidine and pyrimidine groups, the compound exhibits both polar and nonpolar characteristics, impacting its solubility in various solvents.
  • Solvent Compatibility: Typically, organic compounds like this may be more soluble in polar organic solvents, such as:
    • DMSO (Dimethyl sulfoxide)
    • DMF (Dimethylformamide)
    • Ethanol
  • Temperature Dependence: Solubility can often increase with temperature. It is essential to consider the temperature effects when attempting to dissolve this compound in a solvent.
  • pH Sensitivity: The pH of the solution may affect the ionization and hence solubility of the guanidine functional group, making it more soluble under certain conditions.

In practical applications, it is crucial to perform solubility tests to obtain quantitative solubility data, as the theoretical predictions may not reflect real-world behavior. Always consider the specific conditions of your application, as <“solubility is key to reactivity”, influencing how this compound can be utilized effectively in various chemical contexts.

Interesting facts

Exploring 2-(4,6-Dimethylpyrimidin-2-yl)-1-(4-iodophenyl)guanidine

2-(4,6-Dimethylpyrimidin-2-yl)-1-(4-iodophenyl)guanidine is a fascinating compound with unique features that make it an area of interest in the field of medicinal chemistry. Here are some interesting facts about this compound:

  • Role in Research: This compound is often studied for its potential applications in pharmacology, particularly in the development of therapeutic agents.
  • Structural Complexity: The presence of both a pyrimidine ring and a guanidine moiety contributes to its structural diversity, allowing a wide range of interactions with biological targets.
  • Substituent Effects: The 4-iodophenyl group adds significant electronic effects, which can influence the compound's reactivity and interaction with enzymes or receptors.
  • Synthetic Pathways: Researchers have explored various synthetic routes to create this compound, utilizing techniques like nucleophilic substitutions and coupling reactions.
  • Biological Activity: There is ongoing investigation into its biological activity, particularly as an inhibitor in certain enzymatic pathways, which could make it useful in combating diseases.

In summary, 2-(4,6-Dimethylpyrimidin-2-yl)-1-(4-iodophenyl)guanidine exemplifies the intricate relationship between structure and function in chemical compounds. As research progresses, this compound may reveal even more about its potential roles in therapeutic applications.