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Pyrimethanil

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Identification
Molecular formula
C12H13N3
CAS number
53112-28-0
IUPAC name
2-(4,6-dimethylpyrimidin-2-yl)-1-phenyl-guanidine
State
State

At room temperature, pyrimethanil is in a solid state, existing as crystalline powder form.

Melting point (Celsius)
96.10
Melting point (Kelvin)
369.30
Boiling point (Celsius)
342.80
Boiling point (Kelvin)
615.90
General information
Molecular weight
199.26g/mol
Molar mass
199.2660g/mol
Density
1.1600g/cm3
Appearence

Pyrimethanil appears as a white to pale brown crystalline solid. It is often found in powder form and is typically odorless.

Comment on solubility

Solubility of 2-(4,6-dimethylpyrimidin-2-yl)-1-phenyl-guanidine

The solubility of 2-(4,6-dimethylpyrimidin-2-yl)-1-phenyl-guanidine can be characterized as moderately soluble in both water and organic solvents. Understanding its solubility is crucial for various applications, particularly in pharmaceutical formulations and chemical reactions. Here are some key points regarding its solubility:

  • Polar interactions: The presence of polar functional groups influences solubility patterns, enhancing solubility in polar solvents.
  • Hydrogen bonding: The capability to form hydrogen bonds significantly aids in solubility, particularly in aqueous solutions.
  • pH sensitivity: The solubility may vary with pH, as the guanidine group can be protonated under acidic conditions, potentially increasing solubility.

Overall, while it displays reasonable solubility, factors such as solvent choice, temperature, and pH play essential roles in achieving optimal conditions for dissolution. It is advisable to conduct specific solubility tests tailored to the intended application, as "the right solvent can make all the difference."
Additionally, insights into the solubility can help inform better formulation strategies, ultimately enhancing bioavailability and efficacy in therapeutic contexts.

Interesting facts

Interesting Facts about 2-(4,6-Dimethylpyrimidin-2-yl)-1-phenyl-guanidine

The compound 2-(4,6-dimethylpyrimidin-2-yl)-1-phenyl-guanidine is a fascinating molecule known for its potential in various fields, including pharmaceuticals and biochemistry.

Key Characteristics

  • Pharmacological Relevance: This compound has shown promise in medicinal chemistry, particularly as a candidate in the development of agents that influence nitric oxide (NO) production, which is crucial for many physiological processes.
  • Structural Diversity: The presence of both a guanidine group and a pyrimidine ring provides a unique structural framework that can lead to varied biological activities.
  • Potential Applications: Its derivatives may be explored for use in treatments targeting cardiovascular diseases, showcasing the compound's utility beyond mere chemical interest.

Chemical Insights

As a guanidine derivative, the compound exhibits interesting acid-base properties due to the basic nature of the guanidine group. This allows for the formation of salts which can enhance solubility and bioavailability. Furthermore, the dimethylpyrimidine moiety adds to the compound's electronic and steric characteristics, making it a rich subject for chemical investigation.

Citation and Research

Research articles often highlight that such compounds can serve as prototypes for the synthesis of drugs with improved efficacy and reduced side effects. Notably, further exploration into its structure-activity relationship (SAR) could lead to new insights.

In summary, the compound 2-(4,6-dimethylpyrimidin-2-yl)-1-phenyl-guanidine stands at the intersection of synthetic chemistry and biological applications, showcasing how small changes in molecular structure can have significant impacts on biological function. Its diverse potential makes it an exciting area of study for both chemists and biochemists alike.

Synonyms
2-(4,6-dimethylpyrimidin-2-yl)-1-phenylguanidine
1-(4,6-Dimethyl-2-pyrimidinyl)-3-phenylguanidine
1-(4,6-dimethylpyrimidin-2-yl)-3-phenylguanidine
N-(4,6-dimethylpyrimidin-2-yl)-N'-phenylguanidine
N'-(4,6-DIMETHYLPYRIMIDIN-2-YL)-N-PHENYLGUANIDINE
SCHEMBL10498921
SCHEMBL10498925
SCHEMBL10498926
H32173
2-(4,6-dimethylpyrimidin-2-yl)-1-phenyl-guanidine