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Clobetasol Propionate

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Identification
Molecular formula
C25H32ClFO5
CAS number
25122-46-7
IUPAC name
[2-[(4R,8S,12R,19S)-19-chloro-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-8-yl]-2-oxo-ethyl] acetate
State
State

At room temperature, Clobetasol Propionate is typically in a solid state. It is a crystalline powder that can be difficult to dissolve in water.

Melting point (Celsius)
198.50
Melting point (Kelvin)
471.50
Boiling point (Celsius)
395.50
Boiling point (Kelvin)
668.70
General information
Molecular weight
467.90g/mol
Molar mass
467.9040g/mol
Density
1.4300g/cm3
Appearence

Clobetasol Propionate appears as a white to cream-colored crystalline powder. It is practically insoluble in water and freely soluble in acetone and in methylene chloride, soluble in ethanol, and slightly soluble in methanol.

Comment on solubility

Solubility of 2-[(4R,8S,12R,19S)-19-chloro-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-8-yl]-2-oxo-ethyl acetate

The solubility of this complex organic compound is influenced by several factors, including its molecular structure and the functional groups present. Here are key points to consider:

  • Polarity: The presence of polar functional groups, such as the acetate and hydroxy groups, suggests that the compound may have some solubility in polar solvents like water and ethanol.
  • Hydrophobic Regions: The large hydrocarbon framework and multiple methyl groups contribute to hydrophobic characteristics, potentially reducing solubility in water.
  • Solvent Influence: It is likely to be more soluble in organic solvents, such as dimethyl sulfoxide (DMSO) or acetone, due to the compatibly hydrophobic regions.
  • Hydrogen Bonding: The ability of the compound to form hydrogen bonds, particularly from the hydroxy group, may enhance solubility in specific solvents.

As a result, while this compound may exhibit varying solubility depending on the medium, its solubility profile could largely be categorized as moderate, being more soluble in organic solvents compared to water.

Overall, understanding the solubility of this compound is crucial for its applications in chemical processes and formulations.

Interesting facts

Interesting Facts about 2-[(4R,8S,12R,19S)-19-chloro-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-8-yl]-2-oxo-ethyl acetate

This fascinating compound exemplifies the complexity of modern organic chemistry. Known for its unique structural configuration, which features multiple fused rings and various functional groups, it prompts a range of intriguing study areas. Here are some interesting aspects of this compound:

  • Stereochemistry: The presence of specific stereocenters defined by the (R/S) nomenclature offers a rich field for studying chirality and its effects on biological activity.
  • Fluorine's Role: The incorporation of fluorine not only influences the compound's reactivity but also enhances its stability, making it a topic of interest in pharmaceutical research.
  • Potential Applications: Compounds like this may possess significant medicinal properties, suggesting potential applications in drug formulation or agriculture as a herbicide or pesticide.
  • Complexity in Synthesis: The synthesis of such intricate structures often requires advanced techniques in organic synthesis, making it a valuable subject for students and professionals alike.

As stated by noted chemist Linus Pauling, “The structure of a substance is more important than the substance itself.” This compound is a prime example of how structural intricacies can lead to unique properties and functionalities that can drive innovations in chemical sciences.

In summary, 2-[(4R,8S,12R,19S)-19-chloro-12-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icos-17-en-8-yl]-2-oxo-ethyl acetate is not merely a compound; it is a portal into the depths of chemical understanding, beckoning scientists to explore its myriad of potential functionalities and applications.