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Fluocinolone acetonide acetate

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Identification
Molecular formula
C24H30F1O6
CAS number
356-22-9
IUPAC name
[2-[(4R,8S,12S,19S)-19-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl] acetate
State
State

Solid: At room temperature, fluocinolone acetonide acetate is typically found in a solid state as a crystalline powder. Its stability under normal temperature conditions makes it suitable for inclusion in various formulations where a solid state is required for manufacturing and compounding processes.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
494.55g/mol
Molar mass
494.5470g/mol
Density
1.4800g/cm3
Appearence

Fluocinolone acetonide acetate typically appears as a white to off-white crystalline powder. It is insoluble in water but soluble in acetone, chloroform, and ethanol. The crystalline nature may vary slightly depending on the form, but is typically seen as fine crystals.

Comment on solubility

Solubility of the Compound

The solubility of 2-[(4R,8S,12S,19S)-19-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl acetate is influenced by various factors due to its complex structure. Understanding the solubility characteristics of this compound can be dissected into several key aspects:

  • Polarity: The presence of functional groups, such as the ester and hydroxy groups, often enhances the polarity of the compound, affecting its solubility in polar solvents.
  • Solvent Interactions: General trends indicate that compounds with similar polarities tend to dissolve better. Hence, this compound may exhibit good solubility in solvents like ethanol and acetone, while having lower solubility in non-polar solvents.
  • Hydrogen Bonding: The hydroxy group can participate in hydrogen bonding, which may facilitate solubility in aqueous solutions.
  • Temperature Effects: As with many organic compounds, increasing temperature may enhance solubility, allowing this compound to dissolve better at elevated temperatures.
  • Crystallinity: The ability of the compound to form crystals can also impact solubility; more crystalline structures typically have lower solubility compared to their amorphous counterparts.

In summary, while the intricate nature of this compound presents challenges in predicting its solubility, understanding the relationships between polarity, hydrogen bonding, and solvent interactions provides valuable insight into its behavior in various environments. Further empirical studies would help to determine the precise solubility characteristics of this molecule in practical applications.

Interesting facts

Interesting Facts about 2-[(4R,8S,12S,19S)-19-fluoro-11-hydroxy-6,6,9,13-tetramethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxo-ethyl Acetate

This compound, with its intricate structure, represents a fascinating example of synthetic organic chemistry. Known for its complex architecture, it features multiple rings and functional groups that collectively enhance its biological activity. Below are some intriguing aspects that highlight the significance of this compound:

  • Chemical Complexity: The compound contains a pentacyclic framework, making it particularly notable for its structural diversity and potential reactivity.
  • Fluorination: The presence of a fluorine atom is significant, as it can greatly influence the compound's pharmacological properties, including improved metabolic stability and increased lipophilicity.
  • Biological Applications: Compounds with similar structural features have been studied for their therapeutic potential, particularly in areas like oncology and anti-inflammatory treatments.
  • Enzymatic Activity: The hydroxyl group in the structure is often a key feature in biological interactions, suggesting a possible role in enzyme recognition or ligand binding.

In the realm of medicinal chemistry, this compound serves not only as a valuable candidate for drug development but also as a subject of interest for researchers who are keen on exploring structure-activity relationships. Furthermore, the intricate stereochemistry of the compound raises essential questions about chirality and its impact on biological function. As Einstein once said, "The important thing is not to stop questioning. Curiosity has its own reason for existence." This compound certainly evokes curiosity and holds promise for future research endeavors.

Synonyms
DTXSID40963367
2-(12-Fluoro-5-hydroxy-4a,6a,8,8-tetramethyl-2-oxo-2,4a,4b,5,6,6a,9a,10,10a,10b,11,12-dodecahydro-6bH,8H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-6b-yl)-2-oxoethyl acetate