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Brompheniramine

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Identification
Molecular formula
C16H19BrN2O
CAS number
86-22-6
IUPAC name
2-[(5-bromo-2-pyridyl)amino]-1-phenyl-ethanol
State
State

At room temperature, brompheniramine is found in a solid state, typically as a crystalline powder.

Melting point (Celsius)
117.00
Melting point (Kelvin)
390.15
Boiling point (Celsius)
386.60
Boiling point (Kelvin)
659.70
General information
Molecular weight
318.24g/mol
Molar mass
318.1930g/mol
Density
1.4267g/cm3
Appearence

Brompheniramine is typically a white to off-white crystalline powder. It may appear slightly yellow in some cases, depending on the purity.

Comment on solubility

Solubility of 2-[(5-bromo-2-pyridyl)amino]-1-phenyl-ethanol

The solubility of 2-[(5-bromo-2-pyridyl)amino]-1-phenyl-ethanol is influenced by several factors, including its molecular structure and the presence of functional groups. This compound features both a pyridine ring and an ethanol moiety, which can significantly affect its interaction with solvents.

Key Considerations for Solubility:

  • Polar and Nonpolar Characteristics: The hydroxyl group (-OH) in the ethanol part increases polarity, often enhancing solubility in polar solvents such as water and alcohols.
  • Effect of Bromine Substitution: The bromine atom introduces a halogen, which can affect the overall polarity and increase dipole interactions. This may facilitate solubility in certain organic solvents.
  • Hydrogen Bonding: The presence of the amino and hydroxyl groups allows for potential hydrogen bonding, which can improve solubility in water and other protic solvents.

In summary, the solubility of 2-[(5-bromo-2-pyridyl)amino]-1-phenyl-ethanol can be expected to be moderate to high in polar solvents due to its functional groups, but the extent of solubility may vary based on the specific conditions and solute-solvent interactions. As always, empirical testing is recommended to ascertain solubility under various conditions.

Interesting facts

Interesting Facts about 2-[(5-bromo-2-pyridyl)amino]-1-phenyl-ethanol

2-[(5-bromo-2-pyridyl)amino]-1-phenyl-ethanol is an intriguing compound that combines the properties of a pyridine derivative with a phenyl-ethanol structure. This unique amalgamation opens up several avenues in medicinal chemistry and organic synthesis.

Key Highlights:

  • Bioactivity: Compounds like this one can exhibit significant biological activity, making them potential candidates for drug development. The bromine substituent and pyridine ring may enhance interactions with biological targets.
  • Synthesis Techniques: The synthesis of this compound often involves multi-step reactions, incorporating strategies such as nucleophilic substitutions and amine coupling. Such synthetic pathways challenge chemists and often lead to novel methodologies.
  • Research Applications: With its unique structural properties, this compound may play a role in the research of enzyme inhibitors or as a ligand in medicinal chemistry, fostering advancements in pharmaceuticals.
  • Structure-Activity Relationship (SAR): Understanding how variations in its structure affect biological activity is a valuable area of study, particularly in optimizing its pharmacological profile for therapeutic use.

As a compound with both complex chemistry and potential biomedical relevance, 2-[(5-bromo-2-pyridyl)amino]-1-phenyl-ethanol represents the intersection of synthetic science and practical application. Its unique characteristics not only intrigue chemists but also hold promise for real-world solutions in the field of medicine. As quoted by renowned chemists, "The beauty of chemistry lies in its balance between art and science." Each compound adds a unique brushstroke to this fascinating canvas.

Synonyms
1085-13-8
DTXSID701214592
alpha-[[(5-Bromo-2-pyridinyl)amino]methyl]benzenemethanol
I+/--[[(5-Bromo-2-pyridinyl)amino]methyl]benzenemethanol