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5-Fluoro-α-methyltryptamine

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Identification
Molecular formula
C12H15FN2
CAS number
52076-96-7
IUPAC name
2-(5-fluoro-1H-indol-3-yl)-2-methyl-propan-1-amine
State
State

At room temperature, it is typically found as a solid.

Melting point (Celsius)
96.00
Melting point (Kelvin)
369.15
Boiling point (Celsius)
310.50
Boiling point (Kelvin)
583.65
General information
Molecular weight
190.26g/mol
Molar mass
190.2400g/mol
Density
1.2200g/cm3
Appearence

It typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-(5-fluoro-1H-indol-3-yl)-2-methyl-propan-1-amine

The solubility of the compound 2-(5-fluoro-1H-indol-3-yl)-2-methyl-propan-1-amine can be influenced by several factors, including its structural characteristics and interactions with solvents. Here are some key points to consider:

  • Polarity: The presence of the amine functional group typically increases polarity, which can enhance solubility in polar solvents such as water.
  • Hydrogen bonding: The ability to form hydrogen bonds with solvents plays a significant role in solubility. The amine group can contribute to such interactions, making the compound potentially soluble in aqueous solutions.
  • Aromaticity: The indole structure can influence the solubility, as its bulky aromatic system might limit solubility in highly polar solvents.
  • Solvent compatibility: The solubility can greatly vary between different solvents; for instance, it may show different behavior in organic solvents compared to water.

Overall, the solubility of 2-(5-fluoro-1H-indol-3-yl)-2-methyl-propan-1-amine is likely to exhibit a moderate level of solubility in polar solvents, while its behavior in non-polar solvents may be considerably less favorable. Understanding these aspects is crucial for practical applications in pharmaceutical formulations and chemical processes.

Interesting facts

Interesting Facts about 2-(5-Fluoro-1H-indol-3-yl)-2-methyl-propan-1-amine

The compound 2-(5-fluoro-1H-indol-3-yl)-2-methyl-propan-1-amine is a fascinating molecule that has garnered attention in various fields of research, particularly in medicinal chemistry and neuropharmacology.

Key Highlights

  • Structural Diversity: This compound features a unique indole structure, which is a bicyclic structure comprised of a benzene ring fused to a pyrrole ring. Indole derivatives are known for their significant biological activities.
  • Fluorination Effects: The presence of a fluorine atom in the indole moiety often influences the compound's biological properties, enhancing its potency and selectivity in binding to various receptors.
  • Potential Therapeutic Uses: Compounds of this nature have been explored for their roles as potential therapeutic agents in treating mental health disorders, including depression and anxiety, thanks to their interactions with serotonin receptors.
  • Research Interest: Studies have shown that similar structures can exhibit anti-cancer properties by modulating cellular pathways responsible for tumor growth.

Researchers are particularly interested in how the substitution pattern of the indole core affects pharmacological activity. As one expert noted, "Small changes in molecular structure can lead to significant shifts in biological activity." This highlights the importance of carefully designing and synthesizing compounds like 2-(5-fluoro-1H-indol-3-yl)-2-methyl-propan-1-amine to achieve desired effects in pharmacology.

Moreover, ongoing studies are focused on unraveling the mechanisms by which such compounds act at the molecular level, leading to insights that could pave the way for new therapeutic developments.

Synonyms
INDOLE, 3-(2-AMINO-1,1-DIMETHYLETHYL)-5-FLUORO-
14487-94-6
BRN 0397072
5-Fluoro-beta,beta-dimethyltryptamine
DTXSID30162827
DTXCID1085318
5-22-10-00185 (Beilstein Handbook Reference)
2-(5-fluoro-1H-indol-3-yl)-2-methylpropan-1-amine