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2-(5-fluoro-2-nitrophenyl)acetonitrile

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Identification
Molecular formula
C8H5FN2O2
CAS number
445-82-3
IUPAC name
2-(5-fluoro-2-nitro-phenyl)acetonitrile
State
State

At room temperature, 2-(5-fluoro-2-nitrophenyl)acetonitrile is typically in a solid state. It can form crystalline structures that are stable under standard atmospheric conditions.

Melting point (Celsius)
65.00
Melting point (Kelvin)
338.15
Boiling point (Celsius)
316.00
Boiling point (Kelvin)
589.15
General information
Molecular weight
180.14g/mol
Molar mass
180.1370g/mol
Density
1.3940g/cm3
Appearence

2-(5-fluoro-2-nitrophenyl)acetonitrile typically appears as a yellow crystalline solid. The crystals are fine and can vary in exact shade from a light yellow to an amber color depending on the purity and sample size.

Comment on solubility

Solubility of 2-(5-fluoro-2-nitro-phenyl)acetonitrile

2-(5-fluoro-2-nitro-phenyl)acetonitrile is an intriguing compound whose solubility characteristics can be quite fascinating. Understanding its solubility is essential for applications in pharmaceuticals and chemical synthesis.

Solubility Insights

Here are key points regarding the solubility of this compound:

  • Polarity: The presence of the fluoro and nitro groups enhances the overall polarity of the molecule, potentially increasing its solubility in polar solvents.
  • Solvent Compatibility: It is expected to exhibit good solubility in polar aprotic solvents such as dimethyl sulfoxide (DMSO) and acetonitrile, but limited solubility in non-polar solvents.
  • Hydrogen Bonding: The nitrile group may allow for hydrogen bonding interactions with protic solvents, further affecting its solubility behavior.
  • Impurities: The presence of impurities or other solutes in solution can significantly impact the solubility, necessitating careful consideration in experimental setups.

In conclusion, while the exact solubility data for 2-(5-fluoro-2-nitro-phenyl)acetonitrile may not be abundantly available, its molecular structure suggests certain solubility trends worth exploring. It is essential to experiment with various solvents to discern its solubility profile accurately.

Interesting facts

Interesting Facts about 2-(5-Fluoro-2-nitro-phenyl)acetonitrile

2-(5-Fluoro-2-nitro-phenyl)acetonitrile is a fascinating compound that has garnered interest in both academic research and industrial applications. Here are some intriguing points about this compound:

  • Pharmaceutical Relevance: This compound serves as an intermediate in the synthesis of various pharmaceutical agents, particularly in the development of drugs targeting cancer and neurodegenerative diseases.
  • Fluorine's Influence: The presence of fluorine atoms in organic compounds often enhances their biological activity. This makes 2-(5-fluoro-2-nitro-phenyl)acetonitrile a valuable player in medicinal chemistry.
  • Nitro Group Significance: The nitro group in this compound can serve as a pivotal site for further chemical transformations, making it a versatile building block in organic synthesis.
  • Environmental Considerations: As a nitrile, there are important considerations regarding the environmental impact and toxicity of this compound, which necessitates careful handling and usage.
  • Analytical Techniques: The compound can be characterized using various analytical techniques such as NMR and mass spectrometry, which provide insights into its structure and functional groups.

In summary, 2-(5-fluoro-2-nitro-phenyl)acetonitrile not only plays a significant role in the synthesis of essential drugs but also exemplifies the importance of functional group interactions in organic chemistry. Its application in research is a testament to the ongoing quest for novel therapeutic compounds.

Synonyms
2-(5-fluoro-2-nitrophenyl)acetonitrile
5-Fluoro-2-nitrobenzeneacetonitrile
642-621-5
5-Fluoro-2-nitrophenylacetonitrile
3456-75-5
Benzeneacetonitrile, 5-fluoro-2-nitro-
Acetonitrile, (5-fluoro-2-nitrophenyl)-
ACETONITRILE, 2-(5-FLUORO-2-NITROPHENYL)-
MFCD00039742
(5-fluoro-2-nitrophenyl)acetonitrile
BRN 2617246
SCHEMBL10687053
DTXSID20188096
YETOJTGGLXHUCS-UHFFFAOYSA-N
BBL101303
CL8965
STL555099
AKOS005257707
AS-46156
BP-13097
DB-048647
CS-0314088