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Lofexidine

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Identification
Molecular formula
C13H19F3NO2
CAS number
21498-08-8
IUPAC name
2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine
State
State

At room temperature, Lofexidine is a solid substance, usually presented in its crystalline powder form.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
351.00
Boiling point (Kelvin)
624.15
General information
Molecular weight
293.31g/mol
Molar mass
293.3060g/mol
Density
1.3000g/cm3
Appearence

Lofexidine typically appears as a white to off-white crystalline powder. Its crystalline nature contributes to its solidity and defined structure.

Comment on solubility

Solubility of 2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine

The solubility of the compound 2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine (C13H19F3NO2) can be influenced by various factors due to its unique chemical structure. Understanding the solubility of this compound requires considering the following aspects:

  • Polarity: The presence of polar functional groups such as amino (-NH2) and ether (-O-) groups tends to increase solubility in polar solvents like water.
  • Hydrophobic Interactions: The long hydrophobic chain and trifluoromethyl group may hinder solubility in water, suggesting that this compound may be more soluble in organic solvents.
  • Temperature Effects: Increased temperatures can enhance solubility for many organic compounds, making it essential to consider temperature when evaluating solubility.
  • pH Levels: The solubility of compounds with basic or acidic functional groups can vary significantly with the pH of the solution, which could be a crucial factor if used in biological systems.

In summary, while this compound may exhibit good solubility in certain organic solvents, its solubility in water may be limited. It is essential to conduct experimental investigations to determine the precise solubility characteristics under specified conditions, as these could greatly affect its applications and usability in various fields.

Interesting facts

Interesting Facts About 2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine

This fascinating compound, known for its complex structure, embodies a rich tapestry of chemical properties and potential applications. Below are some intriguing aspects:

  • Structural Complexity: The compound features a multifaceted backbone that includes both a methoxy group and a trifluoromethyl substituent. This combination not only adds to its unique properties but also makes it a subject of interest in medicinal chemistry.
  • Pharmacological Potential: Compounds similar to this one have demonstrated potential in various pharmacological applications. Research suggests that structures incorporating amino, ether, and aromatic groups can exhibit biological activity, making this compound a candidate for further studies.
  • Electronic Effects: The presence of the trifluoromethyl group is noteworthy; this group is known for its ability to enhance lipophilicity and metabolic stability. Indeed, “trifluoromethyl groups can dramatically alter the electronic distribution and the overall reactivity of the molecules they are part of.”
  • Versatile Applications: Due to its chemical properties, it can potentially be utilized in various fields including:
    • Medicinal Chemistry
    • Agricultural chemicals as pesticides or herbicides
    • Materials science for developing advanced polymers
  • Research Interest: Ongoing studies in this area focus on understanding how varying substitutions can affect biological interactions. The compound's unique functional groups provide a fertile ground for such research.

In summary, 2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine stands as a noteworthy example of how complex organic compounds can harbor significant potential in scientific innovation and application!

Synonyms
fluvoxamine
2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine
54739-18-3
917096-37-8
(Z)-Fluvoxamine
Luvox (Salt/Mix)
Dumirox (Salt/Mix)
Faverin (Salt/Mix)
Fevarin (Salt/Mix)
Maveral (Salt/Mix)
Floxyfral (Salt/Mix)
61718-81-8
MK-264 (Salt/Mix)
DU-23000 (Salt/Mix)
fluvoxamine-CR
NCGC00018193-06
(Z)-Fluvoxamine - EP
Prestwick0_000995
Prestwick1_000995
SPBio_002980
CHEMBL1621884
BDBM63804
DTXSID70860673
(1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanone o-(2-aminoethyl)oxime #
cid_16682327
AKOS030231239
IF23523
NS00001955
Q27164987
(E)-5-methoxy-1-(4-(trifluoromethyl)phenyl)pentan-1-one O-2-aminoethyl oxime
2-[({5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethan-1-amine
2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethylamine;maleate
(Z)-2-butenedioate;2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine
(Z)-5-Methoxy-1-[4-(triflurormethyl)phenyl]-1-pentanone O-(2-aminoethyl)oxime;Fluvoxamine impurity B
(Z)-but-2-enedioate;2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine