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Nelarabine

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Identification
Molecular formula
C11H15N5O5
CAS number
121032-29-9
IUPAC name
2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
State
State

Solid at room temperature. Typically stable under normal storage conditions.

Melting point (Celsius)
238.50
Melting point (Kelvin)
511.65
Boiling point (Celsius)
280.20
Boiling point (Kelvin)
553.35
General information
Molecular weight
297.30g/mol
Molar mass
297.3040g/mol
Density
1.5700g/cm3
Appearence

Nelarabine is a white to off-white crystalline powder.

Comment on solubility

Solubility of 2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

The solubility of the compound C11H15N5O5 can be influenced by various factors, reflecting its intricate structure. Understanding this solubility is crucial for many chemical and pharmaceutical applications.

Factors Affecting Solubility

  • Polarity: Due to the presence of hydroxymethyl and amino groups, the compound is likely to exhibit a moderate to high level of polarity, potentially leading to better solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds can enhance solubility significantly. The -NH2 groups can donate hydrogen bonds to solvent molecules, while the -OH group contributes as well.
  • Solvent Type: Common solvents such as water or dimethyl sulfoxide (DMSO) may provide a suitable medium for dissolution, while non-polar solvents may struggle.

In summary, the solubility of 2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is expected to be influenced by its polar characteristics and ability to engage in hydrogen bonding, making it soluble in polar organic solvents. Understanding these properties is essential for its practical use in various chemical processes.

Interesting facts

Interesting Facts about 2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

The compound 2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is a fascinating molecule with significant potential in medicinal chemistry, particularly in the field of drug development. Here are some intriguing points about this compound:

  • Biological Relevance: This compound is structurally related to purines, which are vital components of nucleic acids like DNA and RNA. The presence of an aminophenyl group suggests potential interactions with biological targets.
  • Potential Applications: Compounds that contain aminophenyl and purin derivatives are often explored for their roles as anticancer agents, antiviral compounds, or enzyme inhibitors, showcasing their therapeutic promise in treating various diseases.
  • Structural Complexity: The incorporation of both a tetrahydrofuran ring and hydroxymethyl groups adds to its molecular complexity, which can influence its pharmacokinetic properties and receptor interactions.
  • Research Opportunities: Due to its unique structural features, this compound is an interesting candidate for further research in fields such as structural biology and medicinal chemistry.
  • Innovation in Synthesis: The synthesis of such complex organic molecules demands advanced techniques and often involves innovative strategies, reflecting the creativity required in organic synthesis.

In conclusion, 2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol is emblematic of the diversity and potential of chemical compounds in biotechnology. As science progresses, the exploration of such compounds may lead to groundbreaking treatments and a deeper understanding of biochemical processes.

Synonyms
APNEA
N6-2-(4-Aminophenyl)ethyladenosine
CHEMBL326958
2-[6-[2-(4-aminophenyl)ethylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol
[125I]APNEA
[3H]N6-2-(4-Aminophenyl)ethyladenosine
Lopac0_000118
GTPL417
GTPL462
ChEMBL_198532
SCHEMBL16585344
CHEBI:180525
HMS3260G18
Tox21_500118
BDBM50037785
CCG-204213
LP00118
NA72432
SDCCGSBI-0050106.P002
NCGC00015017-02
NCGC00015017-03
NCGC00015017-04
NCGC00015017-05
NCGC00015017-06
NCGC00093612-01
NCGC00093612-02
NCGC00093612-03
NCGC00260803-01
A-202
EU-0100118
L000691
SR-01000075222
SR-01000075222-1
Q27074482
2-(6-{[2-(4-aminophenyl)ethyl]amino}-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol
2-{6-[2-(4-Amino-phenyl)-ethylamino]-purin-9-yl}-5-hydroxymethyl-tetrahydro-furan-3,4-diol